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职业迁徙
个人简介
My research is focused on understanding how extracellular cues regulate cell behaviour in development, tissue regeneration and cancer. We are particularly interested in understanding how signalling pathways are assembled into higher-order networks that confer contextual responses to a cell’s biological output. This led to our key discoveries of intersections between WNT, TGFbeta and the Hippo pathways in stem cells, and the regulation of epithelial cell plasticity. Currently, we are using functional genomics tools coupled to spatio-temporal mapping single-cell profiling to map single-cell state dynamics during tissue morphogenesis, homeostasis and regeneration. This led us to our discovery that damage to the intestine induces a novel cell type we call revival stem cells (revSC) that mediate tissue regeneration by reconstituting a fresh supply of adult, homeostatic stem cells. Our ongoing work seeks to understand how single-cell plasticity is regulated in complex tissues and drives development, tissue regeneration and cancer.
研究兴趣
论文共 417 篇作者统计合作学者相似作者
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crossref(2023)
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David P Cook,Kirk B Jensen, Kellie Wise, Michael J Roache,Felipe Segato Dezem,Natalie K Ryan, Michel Zamojski,Ioannis Vlachos,Simon RV Knott,Lisa M Butler,Jeffrey L Wrana, Nicholas Banovich,
biorxiv(2023)
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crossref(2023)
Adrian K. H. Loe,Abilasha Rao-Bhatia,Zhao Wei, Jung-Eun Kim,Bingxin Guan, Yan Qin, Minji Hong, Hyo Sang Kwak,Xiaoyu Liu, Leyi Zhang,Jeffrey L. Wrana,Haiyang Guo,
CELL REPORTSno. 12 (2023): 113497-113497
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Craig D. Simpson, Imtiaz A. Mawji,Kika Anyiwe, Moyo A. Williams,Xiaoming Wang, Amudha L. Venugopal,Marcela Gronda,Rose Hurren,Sonia Cheng,Stefano Serra,Reza Beheshti Zavareh,Alessandro Datti,
crossref(2023)
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