Dr. Lee's clinical interests include the surgical management of patients with pancreatic cancer, endocrine tumors, and melanoma. Particular areas of interest include the management of borderline resectable pancreatic cancer, vascular resection in pancreatic surgery, multiple endocrine neoplasia, adrenal cortical cancer, neoadjuvant therapy for pancreas and adrenal cancer, minimally invasive adrenal surgery, and surgery for metastatic melanoma. He has had a longstanding peer-review funded collaborative laboratory research effort focused on melanoma genetics, the role of immune and inflammatory blood biomarkers in melanoma, and the development of novel antibody-based therapeutics for melanoma and other cancers.