基本信息
浏览量:66
职业迁徙
个人简介
My research program focuses on cell transplantation strategies to repair the damaged spinal cord. We have shown that a number of cell types can both remyelinate the demyelinated CNS and encourage CNS axonal regeneration. Our laboratory utilizes a number of cellular and electrophysiological techniques to study cell transplant-induced repair.
While most of our work utilizes rodent models, we also use nonhuman primates. Although direct surgical implantation of cells is a reasonable approach for cell delivery in single lesion sites, multiple sclerosis is complicated by numerous demyelinated sites within the CNS. We have shown that intravenous delivery of a bone marrow cell fraction enriched with mesenchymal stem cells (MSCs) can home to a demyelinated lesion in the rodent spinal cord and remyelinate the damaged axons.
While most of our work utilizes rodent models, we also use nonhuman primates. Although direct surgical implantation of cells is a reasonable approach for cell delivery in single lesion sites, multiple sclerosis is complicated by numerous demyelinated sites within the CNS. We have shown that intravenous delivery of a bone marrow cell fraction enriched with mesenchymal stem cells (MSCs) can home to a demyelinated lesion in the rodent spinal cord and remyelinate the damaged axons.
研究兴趣
论文共 70 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Tatsuro Yamashita,Masanori Sasaki,Yuichi Sasaki,Hiroshi Nagahama,Shinichi Oka,Yuko Kataoka-Sasaki,Ryo Ukai,Takahiro Yokoyama, Masato Kobayashi,Masafumi Kakizawa,Jeffery D. Kocsis,Osamu Honmou
BRAIN RESEARCH (2024): 148709-148709
Brain research (2021): 147296-147296
Masahito Nakazaki,Shinichi Oka,Masanori Sasaki,Yuko Kataoka-Sasaki,Rie Onodera,Katsuya Komatsu,Satoshi Iihoshi, Manabu Hiroura, Akira Kawaguchi,Jeffery D Kocsis,Osamu Honmou
PloS oneno. 1 (2018): e0190358-e0190358
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn