Jeff T. Hutchins

Inhibitex, Inc. 9005 Westside Parkway, Alpharetta, GA 30009, USA

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Papers30 papers

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DMPK and Metabolism Studies of Nucleoside Phosphoramidates Including INX-08189, A Novel Double Pro-drug and Clinical Candidate for Hepatitis C Virus Therapy

Jeff T. Hutchins,Christopher McGuigan,Stanley D. Chamberlain,Karolina W. Madela,Mohamed Aljarah,John Vernachio,Joseph M. Patti,Geoffrey Henson

Antiviral Research, no. 2 (2011): A22-A23

Cited by1EIBibtex

Surface proteins from coagulase-negative staphylococci and Staphylococcus aureus that generate cross-reactive monoclonal and polyclonal antibodies

Timothy J Foster, Fiona Roche,Mark J Pallen,Joseph M Patti,Jeff T Hutchins,Pietro Speziale

(2011)

Cited by1Bibtex

Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus

Christopher McGuigan,Karolina Madela,Mohamed Aljarah,Arnaud Gilles,Srinivas K Battina,Changalvala V S Ramamurty,C Srinivas Rao,John Vernachio,Jeff Hutchins,Andrea Hall,Alexander Kolykhalov,Geoffrey Henson

Bioorganic & Medicinal Chemistry Letters, no. 19 (2011): 6007-6012

Cited by16WOSEIBibtex

Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus

Christopher McGuigan,Karolina Madela,Mohamed Aljarah,Arnaud Gilles,Andrea Brancale,Nicola Zonta,Stanley Chamberlain,John Vernachio,Jeff Hutchins,Andrea Hall,Brenda Ames,Elena Gorovits

Bioorganic & Medicinal Chemistry Letters, no. 16 (2010): 4850-4854

Cited by60WOSEIBibtex

Metabolite characterization of INX-189, a potent HCV inhibitor, in fresh human primary hepatocytes and human liver and kidney cell lines [abstract 1874]

Andrea Hall,Nicholas Raja,Stanley Chamberlain,Elena Gorovits,Geoffrey Henson,Jeff T Hutchins,Jerry Muhammad,Joseph M Patti,John Vernachio, J Wang,Karolina Madela,Mohamed Aljarah

(2010)

Bibtex

In vitro and in vivo metabolism of INX-189, a potent HCV inhibitor, in rat and cynomolgus monkey hepatocytes [Abstract]

John Vernachio,David J Bryant,Stanley Chamberlain,Elena Gorovits,Babita Ganguly, A S Hall,Geoffrey Henson,Damound Hunley,Jeff T Hutchins,Jerry Muhammad,Joseph M Patti, Chad Walters

(2010)

Cited by1Bibtex

Phosphoramidate ProTides of 2′-C-Methylguanosine as Highly Potent Inhibitors of Hepatitis C Virus. Study of Their in Vitro and in Vivo Properties

Christopher McGuigan,Arnaud Gilles,Karolina Madela,Mohamed Aljarah,Sabrina Holl,Sarah Jones,John Vernachio,Jeff Hutchins,Brenda Ames,K. Dawn Bryant,Elena Gorovits,Babita Ganguly

Journal of Medicinal Chemistry, no. 13 (2010): 4949-4957

Bibtex

MONOCLONAL ANTIBODIES RECOGNIZING A COAGULASE-NEGATIVE STAPHYLOCOCCAL PROTEIN

Joseph M Patti,Jeff T Hutchins,Andrea Hall, Linda Santos, M G Bowden,Magnus Hook

(2010)

Cited by3Bibtex

Monoclonal antibodies specific for Candida albicans Als3 that immunolabel fungal cells in vitro and in vivo and block adhesion to host surfaces

David A. Coleman,Soon-Hwan Oh,Xiaomin Zhao,Hongyuan Zhao,Jeff T. Hutchins,John H. Vernachio,Joseph M. Patti,Lois L. Hoyer

Journal of Microbiological Methods, no. 1 (2009): 71-78

Cited by34EIWOSBibtex

Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby

Magnus Hook,Yi Xu,Jouko Sillanpaa,Narayana Sthanam,Karthe Ponnuraj,Joseph M Patti,Jeff T Hutchins,Andrea Hall, M G Bowden

(2009)

Cited by7Bibtex

Monoclonal antibodies to the CLFA protein and method of use in treating infections

Joseph M Patti,Jeff T Hutchins, Paul Domanski, P R Patel,Andrea Hall

(2008)

Cited by3Bibtex

Anticorps monoclonaux à réactivité croisée reconnaissant les protéines de type als

Elena Gorovits,Lois L Hoyer,Jeff T Hutchins,Joseph M Patti, Linda Santos,John Vernachio,Hongyuan Zhao,Xiaomin Zhao

(2007)

Bibtex

Monoclonal antibodies recognizing the Enterococcus faecalis collagen-binding MSCRAMM Ace: Conditional expression and binding analysis

Andrea E. Hall,Elena L. Gorovits,Peter J. Syribeys,Paul J. Domanski,Brenda R. Ames,Cathy Y. Chang,John H. Vernachio,Joseph M. Patti,Jeff T. Hutchins

Microbial Pathogenesis, no. 2 (2007): 55-66

Cited by15EIWOSBibtex

Cross-reactive monoclonal antibodies recognizing als family proteins

Elena Gorovits,Lois L Hoyer,Jeff T Hutchins,Joseph M Patti, Linda Santos,John Vernachio,Hongyuan Zhao,Xiaomin Zhao

(2007)

Bibtex

Monoclonal antibodies to the fibronectin binding protein and method of use in treating or preventing infections

Joseph M Patti, P N Patel,Andrea Hall, Paul Domanski,Peter Syribeys,Jeff T Hutchins

(2006)

Cited by10Bibtex

Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580

James G. Conway,Brad McDonald,Janet Parham,Barry Keith,David W. Rusnak,Eva Shaw,Marilyn Jansen, Peiyuan Lin,Alan Payne,Renae M. Crosby,Jennifer H. Johnson,Lloyd Frick

Proceedings of the National Academy of Sciences of the United States of America, no. 44 (2005): 16078-16083

Cited by167WOSBibtex

Monoclonal and polyclonal antibodies recognizing coagulase-negative staphylococcal proteins

Joseph M Patti,Jeff T Hutchins,Andrea Hall, Paul Domanski, P N Patel,Magnus Hook,Jeffrey Robbins,John Vernachio, M G Bowden

(2003)

Bibtex

Monoclonal antibodies to the ClfA protein and method of use in treating or preventing infections

Joseph M Patti,Jeff T Hutchins, Paul Domanski, P R Patel,Andrea Hall

(2002)

Cited by20Bibtex

Anticorps monoclonaux et polyclonaux a reaction croisee qui reconnaissent des proteines de surface de staphylocoques a coagulase negative et de staphylocoques dores

Timothy J Foster, Fiona M Roche,Joseph M Patti,Jeff T Hutchins,Andrea Hall, Paul Domanski, P N Patel,Peter Syribeys,Pietro Speziale

(2002)

Bibtex

Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and staphylococcus aureus

Timothy J Foster, Fiona Roche,Joseph M Patti,Jeff T Hutchins,Andrea Hall, Paul Domanski, P N Patel,Peter Syribeys,Pietro Speziale

(2002)

Cited by25Bibtex

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