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Cells connect and communicate via an information superhighway named gap junctions. Gap junctions are clusters of transmembrane channels that connect the cytoplasm of adjacent cells. These channels are formed by a family of proteins called connexins. Gap junction channels permit small metabolites, ions, and second messengers to pass from cell to cell. Cells like lens fibers within the interior of the vertebrate eye lens neither have blood supply nor organelles. Thus, lens survival and homeostasis are uniquely dependent upon intercellular communication via gap junctions with the cells localized at the lens surface. For cells like bone osteocytes, signals generated by mechanical loading can be transmitted extensively through gap junction channels. Therefore, gap junctions provide the critical means for cell survival and for physiological regulation of cellular functions. In addition to forming gap junctions, connexins are recently shown to form hemichannels, un-apposed halves of gap junction channels. Hemichannels mediate the passage of biological molecules, especially for cells under stress conditions. Our current research interests are:
1). To determine the gap junction or hemichannel-dependent and independent mechanisms of connexins in cell growth, differentiation and lens development.
2). To investigate the functional significance of gap junctions, hemichannels and integrins in signaling transmission, skeletal tissue remodeling and cancer metastasis of breast cancer and osteosarcoma.
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Jiang-Hui Meng, Yong-Biao Huang, Jin Long,Qiu-Chen Cai, Xin Qiao, Qiong-Li Zhang,Li-Dan Zhang, Xiang Yan, Rui Jing, Xing-Shan Liu, Sai-Jun Zhou, Yong-Sheng Yuan,
iScienceno. 4 (2024): 109469-109469
Methods in molecular biology (Clifton, N.J.) (2024): 111-124
JOURNAL OF BONE AND MINERAL RESEARCH (2023): 25-25
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Rui Hua,Yan Han,Anahi Tinajero,Qingwen Ni, Truong A. Vu, Roberto J. Fajardo,Xiaodu Wang,Jean X. Jiang
JOURNAL OF BONE AND MINERAL RESEARCH (2023): 112-112
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JOURNAL OF BONE AND MINERAL RESEARCH (2023): 60-60
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