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New therapeutics are still likely emerge in coming years from the foundations he laid in the field of CRF. Beyond the borders of mammalian physiology, he became intrigued with conotoxins, extremely venemous and complex multicyclic peptides derived from tropical cone snails. A fitting challenge to a synthetic chemist of his caliber, he synthesized many of these and their analogs including ziconotide which is marketed for the treatment of severe pain. His work on isolation of new peptides and developing and unselfishly sharing synthetic peptide tools with collaborators around the world led to more than 1,200 publications across broad swaths of biology.
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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICSno. 2 (2015): 307-317
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Renzo Cescato, Kimberly A Loesch,Beatrice Waser,Helmut R Mäcke,Jean E Rivier,Jean Claude Reubi,Agnes Schonbrunn
Judit Erchegyi, Jozsef Gulyas,Marilyn Perrin, Charleen Miller,Kathy Lewis,Wolfgang Fischer, Cindy Donaldson,Jean Rivier
Peptides Across the Pacific: The Proceedings of the Twenty-Third American and the Sixth International Peptide Symposium (2013)
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