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个人简介
Dr. Locasale has been one of the pioneers the use of metabolomics approaches to study cancer biology and metabolism. He has made seminal contributions to our understanding of metabolism including the discovery of serine synthesis in cancers, defining the quantitative, mechanistic principles of the Warburg Effect and altered glucose metabolism in cancer, and the role of metabolism in mediating chromatin status and epigenetics, and the role of dietary amino acids in cancer. His research combines quantitative approaches in metabolomics and mathematical modeling with biochemistry, cell biology and genetics.
His current research interests are in three areas: 1) Quantitative biology of metabolism, 2) The role of diet and metabolic therapeutics in health and cancer, and 3) The mechanistic basis between the interaction of metabolism and epigenetics. Each of these synergistic areas utilizes the metabolomics technologies and computational approaches that he develops, applies, and disseminates.
As illustrative recognitions, Dr. Locasale currently serves on a number of editorial boards including PLoS Biology and has served numerous advisory roles for industry, philanthropic organization, and government including the National Institutes of Health office of the Director, and the National Cancer Institute. He has operated a laboratory funded primarily by NIH with foundation awards, training fellowships and core services. He has authored over 175 publications and numerous textbooks chapters and patents. He has been invited to named lectures in at least twenty countries across Europe, Asia, the Middle East and the Americas.
His current research interests are in three areas: 1) Quantitative biology of metabolism, 2) The role of diet and metabolic therapeutics in health and cancer, and 3) The mechanistic basis between the interaction of metabolism and epigenetics. Each of these synergistic areas utilizes the metabolomics technologies and computational approaches that he develops, applies, and disseminates.
As illustrative recognitions, Dr. Locasale currently serves on a number of editorial boards including PLoS Biology and has served numerous advisory roles for industry, philanthropic organization, and government including the National Institutes of Health office of the Director, and the National Cancer Institute. He has operated a laboratory funded primarily by NIH with foundation awards, training fellowships and core services. He has authored over 175 publications and numerous textbooks chapters and patents. He has been invited to named lectures in at least twenty countries across Europe, Asia, the Middle East and the Americas.
研究兴趣
论文共 318 篇作者统计合作学者相似作者
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Andrew J. Monteith,Haley E. Ramsey, Alexander J. Silver,Donovan Brown,Dalton Greenwood,Brianna N. Smith, Ashley D. Wise,Juan Liu, Sarah D. Olmstead, Jackson Watke,Maria P. Arrate,Agnieszka E. Gorska,
crossref(2024)
biorxiv(2024)
Andrew J. Monteith,Haley E. Ramsey, Alexander J. Silver,Donovan Brown,Dalton Greenwood,Brianna N. Smith, Ashley D. Wise,Juan Liu, Sarah D. Olmstead, Jackson Watke,Maria P. Arrate,Agnieszka E. Gorska,
crossref(2024)
Charles Swanton, Elsa Bernard, Chris Abbosh,Fabrice André,Johan Auwerx,Allan Balmain,Dafna Bar-Sagi,René Bernards,Susan Bullman,James DeGregori, Catherine Elliott,Ayelet Erez,
Cellno. 7 (2024): 1589-1616
Andrew J. Monteith,Haley E. Ramsey, Alexander J. Silver,Donovan Brown,Dalton Greenwood,Brianna N. Smith, Ashley D. Wise,Juan Liu, Sarah D. Olmstead, Jackson Watke,Maria P. Arrate,Agnieszka E. Gorska,
crossref(2024)
Yudong Sun,Jason W. Locasale
Ran Zhang, Jingqi Fang,Xueshu Xie,Chris Carrico,Jesse G. Meyer,Lei Wei,Joanna Bons,Jacob Rose,Rebeccah Riley,Ryan Kwok, Prasanna Vadhana Ashok Kumaar, Yini Zhang,
Nature Metabolismno. 3 (2024): 550-566
bioRxiv : the preprint server for biology (2024)
Andrew J Monteith,Haley E Ramsey, Alexander J Silver,Donovan Brown,Dalton Greenwood,Brianna N Smith, Ashley D Wise, Juan Liu, Sarah D Olmstead, Jackson Watke,Maria P Arrate,Agnieszka E Gorska,
Cancer research (2024)
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