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个人简介
The Harper Lab studies mechanisms underlying cellular homeostasis and signaling, with a focus on the ubiquitin system and the autophagy-lysosome system. The interest in the ubiquitin-proteasome system in the Harper Lab initially emerged through studies to understand how cell cycle regulators (cyclins and CDK inhibitors) are degraded to control cell cycle transitions, resulting in the discovery of cullin-RING ubiquitin ligases, and their roles in phosphorylation-dependent protein degradation. The Harper Lab currently uses quantitative proteomics, imaging, and biochemical approaches to elucidate underlying biochemical mechanisms controlling protein turnover, and applies these approaches to examine regulatory pathways relevant to various neurodegenerative disease, including Parkinson’s and Alzheimer’s diseases. A major focus currently is the PARKIN ubiquitin ligase, which controls turnover of damaged mitochondria via the autophagy pathway and is mutated in Parkinson’s Disease. The Harper Lab, together with the Gygi Lab at HMS, is also using proteomics to develop a large-scale human protein interaction network including the majority of proteins encoded by the human genome.
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论文共 430 篇作者统计合作学者相似作者
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Leah V. Schaffer, Mengzhou Hu,Edward L. Huttlin, Gege Qian, Abantika Pal,Neelesh Soni, Andrew Latham,Laura Pontano Vaites,Trang Le,Yue Qin,Christopher Churas,Dexter Pratt,
Cancer Researchno. 6_Supplement (2024): 2348-2348
crossref(2024)
J Wade Harper,Felix Kraus,Yuchen He,Sharan Swarup,Katherine A Overmyer, Johann Brenner,Cristina Capitanio,Anna Bieber,Annie Jen, Nicole M Nightingale, Benton J Anderson, Chan Lee,
crossref(2024)
Mengzhou Hu,Leah V. Schaffer,Edward L. Huttlin, Gege Qian, Andrew Latham, Abantika Pal,Laura Pontano Vaites,Trang Le,Yue Qin,Christopher Churas,Dexter Pratt,Robin Bachelder,
Cancer Researchno. 6_Supplement (2024): 6543-6543
bioRxiv (Cold Spring Harbor Laboratory) (2024): 1327361-1327361
Felix Kraus,Yuchen He,Sharan Swarup,Katherine A Overmyer,Yizhi Jiang, Johann Brenner,Cristina Capitanio,Anna Bieber,Annie Jen, Nicole M Nightingale, Benton J Anderson, Chan Lee,
bioRxiv : the preprint server for biology (2024)
Benjamin L. Springstein,Joao A. Paulo,Hankum Park, Kemardo Henry,Eleanor Fleming, Zoe Feder,J. Wade Harper,Ann Hochschild, Hani S. Zaher
bioRxiv (Cold Spring Harbor Laboratory)no. 8 (2023)
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