His clinical areas of expertise include bone marrow failure syndromes (including aplastic anemia, myelodysplastic syndrome, large granular lymphocyte leukemia, paroxysmal nocturnal hemoglobinuria), and myeloid malignancies. His research deals with the molecular pathogenesis of these disorders and deals with various specific aspects of stem cell biology, genetics, cytogenetics and immunobiology. He has developed multiple whole genome scanning technologies for laboratory and diagnostic use, including SNP-arrays, methylation arrays and viral chips.