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Skeletal Development, Bone Biology and PathologyBone tissue functions as a mechanically responsive structural component of the body and as a major organ essential for maintaining calcium and phosphate homeostasis. The skeleton is the target of numerous human genetic disorders and numerous mouse models have identified new regulatory pathways that affect the skeleton. As a normal process of aging and hormonal changes after the menopause, skeletal mass can decrease by as much as 30% leading to bone fracture and compromised quality of life in the elderly population. Historically the laboratory has addressed molecular mechanisms regulating formation and mineralization of bone by osteoblasts and turnover of bone tissue by osteoclasts, the bone resorbing cells. We are defining the key regulatory events for the progressive differentiation of osteoprogenitor stem cells to osteogenic cells by identifying epigenetic, transcriptional and microRNA regulation of tissue-specific genes.
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Kirsten M. Tracy, Shannon Prior, Willem T. Trowbridge,Joseph R. Boyd,Prachi N. Ghule,Seth Frietze,Janet L. Stein,Gary S. Stein,Jane B. Lian
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSIONno. 2 (2024): 61-72
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Prachi N. Ghule,Joseph R. Boyd, Fleur Kabala,Andrew J. Fritz,Nicole A. Bouffard,Cong Gao, Kathleen Bright, Jill Macfarlane,David J. Seward,Gianluca Pegoraro,Tom Misteli,Jane B. Lian,
Kyle C. Kurek, Sara Del Mare,Zaidoun Salah,Suhaib Abdeen,Hussain Sadiq, Suk-hee Lee,Eugenio Gaudio,Nicola Zanesi,Kevin B. Jones, Barry DeYoung, Gail Amir,Mark Gebhardt,
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