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The goal of our research is to elucidate the early innate immune/inflammatory mechanisms by which cSiO2 elicits autoimmune effects and how DHA interferes with these events. This project will be the first step toward a mechanistic understanding of how dietary modulation of the lipidome could be used to prevent triggering of lupus. This knowledge is essential to develop practical, low-cost preventative strategies to help individuals environmentally exposed to cSiO2 and potentially other toxicants to reduce their risk for developing lupus or other AD. It will further be relevant as an intervention for stopping flare-ups and slowing progression of existing autoimmunity . We also anticipate our studies will reveal potential benefits of ω-3 consumption on other pulmonary inflammatory diseases, such as silicosis, another understudied area. New knowledge produced by this research project could help decrease morbidity and mortality associated with toxicant-triggered inflammation and autoimmunity, and reduce health care costs related to lupus and other AD.
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Lauren K Heine, Tasha Scarlett,James G Wagner,Ryan P Lewandowski,Abby D Benninghoff, Ashleigh N Tindle, Anna E Skedel,Jack R Harkema,James J Pestka
Inhalation toxicologyno. 2 (2024): 106-123
FRONTIERS IN IMMUNOLOGY (2024): 1275265-1275265
Frontiers in Immunology (2023): 1274147-1274147
Olivia K Favor,Preeti S Chauhan, Elham Pourmand, Angel M Edwards,James G Wagner,Ryan P Lewandowski,Lauren K Heine,Jack R Harkema,Kin Sing Stephen Lee,James J Pestka
Lauren K. Heine,Abby D. Benninghoff,Elizabeth A. Ross,Lichchavi D. Rajasinghe,James G. Wagner,Ryan P. Lewandowski, Alexa L. Richardson,Quan-Zhen Li,John P. Buchweitz,Justin Zyskowski, Ashleigh N. Tindle, Anna E. Skedel,
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