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个人简介
He earned the 2018 Nobel Prize in Physiology or Medicine, which he shared with Dr. Tasuku Honjo, "for their discovery of cancer therapy by inhibition of negative immune regulation." Among his most notable discoveries are the determination of the T cell receptor structure and that CD28 is the major costimulatory molecule that allows full activation of naïve T cells and prevents anergy in T cell clones. His lab resolved a major controversy by demonstrating that CTLA-4 inhibits T-cell activation by opposing CD28-mediated costimulation and that blockade of CTLA-4 could enhance T cell responses, leading to tumor rejection in animal models. This finding and a great deal of persistence paved the way for the field of immune checkpoint blockade therapy for cancer. Work in his lab led to the development of ipilimumab, an antibody to human CTLA-4 and the first immune checkpoint blockade therapy approved by the FDA. Among many honors, he is a member of the National Academies of Science and Medicine and received the Lasker-Debakey Clinical Medical Research award in 2015. His current work seeks to improve immune checkpoint blockade therapies currently used by our clinicians and identify new targets to unleash the immune system in order to eradicate cancer.
研究兴趣
论文共 679 篇作者统计合作学者相似作者
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Cancer Researchno. 6_Supplement (2024): 5486-5486
Cancer Researchno. 6_Supplement (2024): 1354-1354
EUROPEAN JOURNAL OF CANCER (2024): 113501-113501
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Katharina Kreymborg,Stefan Haak,Rajmohan Murali, Joyce Wei,Rebecca Waitz,Georg Gasteiger,Peter A. Savage, Marcel R. M. van den Brink,James P. Allison
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Charlotte E. Ariyan,Mary Sue Brady, Robert H. Siegelbaum,Jian Hu, Danielle M. Bello, Jamie Rand, Charles Fisher, Robert A. Lefkowitz, Kathleen S. Panageas,Melissa Pulitzer,Marissa Vignali,Ryan Emerson,
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Cellno. 8 (2023): 1652-1669
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