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Dr. Kochenderfer develops T-cell therapies for blood cancers including lymphoma, leukemia, and multiple myeloma. T cells normally play a critical role in fighting infections and cancers. Patients who have cancer have T cells that are no longer fighting their cancer. With gene therapy, their T cells can be modified to attack a cancer target and exert a powerful and specifically-targeted anti- cancer effect. Dr. Kochenderfer leads a lab that genetically engineers T cells with genes encoding chimeric antigen receptors (CAR) that target malignancy-associated antigens. He previously designed and constructed a novel anti-CD19 CAR T cell that was first to demonstrate antigen-specific activity of anti-CD19 CAR T cells in humans. This work in anti-CD19 CAR T cells led to the first Food and Drug Administration-approved CAR T-cell therapy for lymphoma. Dr. Kochenderfer also designed the first chimeric antigen receptor targeting B-cell maturation antigen (BCMA). He then led the first clinical trial of T cells expressing an anti-BCMA CAR as a treatment for multiple myeloma. He currently has open trials investigating novel CAR T cell therapies in Multiple Myeloma and Lymphoma and is developing new methods to improve the cancer fighting ability of CAR T cells.
研究兴趣
论文共 84 篇作者统计合作学者相似作者
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Molecular Therapy (2024)
Nathaniel J Kochenderfer,James N Kochenderfer
Journal of Emerging Investigators (2024)
Christina Amatya, Katherine A. Weissler,Vicki Fellowes,Norris Lam,Lauren C. Cutmore,Danielle A. Natrakul,Steven L. Highfill,James N. Kochenderfer
Molecular Therapy - Methods & Clinical Developmentno. 1 (2024): 101212-101212
Lekha Mikkilineni,Danielle A. Natrakul,Norris Lam,Elisabet E. Manasanch,Jennifer Mann, Katherine A. Weissler,Nathan Wong,Jennifer N. Brudno,Stephanie L. Goff,James C. Yang, Micaela Ganaden,Rashmika Patel,
MOLECULAR THERAPYno. 2 (2024): 503-526
Molecular Therapy: Oncolytics (2023): 132-149
Bone marrow transplantationno. 10 (2023): 1157-1159
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