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Alterations in ion channel expression is an established finding in many cancers. Expression of distinct channel types in malignacies may underlie altered patterns of gene expression, tumour invasion and malignant cell proliferation. Examination of the alterations in channel phenotype can be used as a diagnostic tool for identification of some cancer subtypes. Driven by my long standing interest in megakaryocyte calcium signaling and ion channel expression, my laboratory has focused upon the documented loss of voltage-activated potassium channel function in megakaryocytes from patients suffering from acute myelogenous leukaemia. Suppression of this critical membrane potential controlling ion channel is associated with the malignacy since chemotherapy-induced remission results in normal voltage-activated potassium channel function.
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Resuscitation Plus (2023): 100430-100430
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medRxivno. 1 (2023): 1-11
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BMJ openno. 10 (2023): e079328-e079328
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A. Siriwardena, S. Jegatheeswaran,J. Mason, M. Baltatzis, A. Sheen,D. O'Reilly,S. Jamdar,R. Deshpande,N. de Liguori Carino, T. Satyadas, A. Qamruddin
Efficacy and Mechanism Evaluationno. 03 (2023)
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The bone & joint journalno. 4 (2023): 382-388
The Bone & Joint Journalno. 1 (2023): 47-55
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The bone & joint journalno. 1 (2023): 47-55
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