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Dr. Binley has spent his career working on the antibody response to HIV, with a particular interest in vaccine development. In 1991 he made phage displayed antibody libraries from HIV+ patient bone marrow. He then “panned” (selected) these libraries against various antigens to try to discover new broadly neutralizing monoclonal antibodies (bNAbs). These bNAbs are important for vaccine development, because they provide a blueprint for vaccines that aim to induce similar bNAbs to fend off infection. In 1995, Dr. Binley became heavily involved in research on the impact of newly emerging high active antiviral drug therapies that can reduce the levels of HIV in the blood of infected people to below detectable levels. Later, he began working on an HIV vaccine to elicit bNAbs. By this time, it had become increasingly clear that bNAbs uniquely recognize the native form of the HIV spike protein, but most antibodies, including those induced by vaccines up to that point, could not bind effectively. Accordingly, it became increasingly clear that for vaccines to be effective, they would need to look more like native spikes.
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Alessio D'Addabbo,Tommy Tong, Emma Crooks,Keiko Osawa,Jiamin Xu, Alyssa Thomas,Joel Allen,Max Crispin,James M Binley
biorxiv(2024)
PLoS pathogensno. 8 (2023): e1011452-e1011452
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Emma T Crooks, Francisco Almanza,Alessio D'Addabbo,Erika Duggan,Jinsong Zhang,Kshitij Wagh,Huihui Mou,Joel D Allen, Alyssa Thomas,Keiko Osawa,Bette T Korber,Yaroslav Tsybovsky,
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