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个人简介
Dr. Herman's major research interests include structural, functional and molecular biological principles underlying brain stress integration.
Research Description: The brain is at the center of a complex physiological process orchestrating secretion of stress hormones. Integration of the stress response occurs by way of a defined array of central stress-integrative neurons, which initiate a neuroendocrine cascade resulting in steroid secretion by the adrenal glands.
Dr. Herman's laboratory is geared toward examining the relationship between the physiological actions of central nervous system stress circuits and their place in the central nervous system.
Present studies focus on:
1) limbic system regulation of the stress response and, consequently, on the generation of stress-related disorders, ranging from major depressive illness to essential hypertension to neurodegeneration and aging, and
2) defining the role of central adrenocorticosteroid receptors in transducing stress-related signals in normal physiology, aging and disease states.
Experimental approaches include in situ hybridization, RNAse protection and PCR methods for localizing and quantifying gene expression and mRNA levels in identified neuronal populations; immunoautoradiography, Western blot and gel mobility shift assays for assessing regulation and functional integrity of stress-related proteins; and combinations of in situ hybridization, immunohistochemistry and tract-tracing for establishing the biochemical signatures of defined circuits within the brain-stress axis.
研究兴趣
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Jason Radley, Mariana Pais,Jason Radley,James P. Herman, Flor van Maanen,Marian Joëls,Elbert Geuze,Milou Sep
Psychoneuroendocrinology (2024): 106738
Psychoneuroendocrinology (2024): 106739
IBRO neuroscience reports (2023): S62-S62
Cristiane Busnardo, Luana Giatti, Bianca Scarambone, Lucas De Souza,Lucas Barretto-De-Souza,Fernando Corrêa,James Herman,Fabio Cruz,Carlos Crestani
IBRO Neuroscience Reports (2023): S61-S62
Kimberly L Kraus,Nawshaba Nawreen,Christin M Godale, Arihant P Chordia, Ben Packard,Candi L LaSarge,James P Herman,Steve C Danzer
Evelin M. Cotella,Nawshaba Nawreen,Rachel D. Moloney,Susan E. Martelle, Kristen M. Oshima,Paige Lemen, Jordan N. Niblack, Reetu R. Julakanti,Maureen Fitzgerald,Mark L. Baccei,James P. Herman
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCEno. 2 (2023): 274-282
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