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The application of protein structure determination by X-ray crystallography coupled to molecular biology and biochemistry to probe biological mechanisms and to target specific disease pathways. We have ongoing research in 1) signal transduction 2) physical basis of protein carbohydrate interactions 3) pathogenic bacteria glycan assembly, we have cloned and crystallised a number of the enzymes involved in key steps of glycan synthesis in pathogenic bacteria. 4) viral replication, we are purifying and crystallising a heterodimer crucial to replication of viruses in vivo, 5) the biosynthesis of unusual natural products.
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论文共 350 篇作者统计合作学者相似作者
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ULTRAMICROSCOPY (2024): 113882-113882
Lachlan P Deimel, Lucile Moynie,Guoxuan Sun, Viliyana Lewis, Abigail Turner,Charles J Buchanan,Sean A Burnap,Carolin M Kobras,Mathew Stracy,Weston B Struwe,Andrew J Baldwin,James Naismith,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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The Journal of biological chemistryno. 11 (2023): 105337-105337
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Open biologyno. 3 (2023): 220373
Lachlan P. Deimel,Xiaochao Xue, Aziz Khan, L. Moynié,Charles Buchanan,Guoxuan Sun,Ryan McBride,Heiko Schuster, Charles Gauthier, Rima M. Saliba,Karolis Leonavicius, Leanne Minall,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
IUCrJno. 3 (2023): 270-287
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