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He more recently did pioneering work on discovering stem cells in the corneal stroma and applying them translationally to cure corneal scarring. This was first shown in mice and was being applied in clinical trials with colleagues in India to treat humans with blinding corneal scars. This resulted in paradigm shifting publications in Stem Cells (PMID 19544455) and Science Translational Medicine (PMID 25504883). His promising early results support the idea that existing corneal scars can be remodeled and resolved by a single treatment with stem cells. He had also established, with Dr. Fatima Syed-Picard, now Faculty of the School of Dentistry at Pitt, that stem cells from teeth had the potential to mediate the same corneal repair mechanisms, resulting in the nation’s popular press taking note of the real meaning of “Eye Teeth”! Jim was working with collaborators to apply his discoveries with articial collagen matrices to bioengineer artificial corneas. He was working on the underlying mechanisms by which corneal stromal stem cells and stem cell exosomes act, right up to just a few weeks before his untimely passing.
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CORNEAL REGENERATION: THERAPY AND SURGERY (2019)
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