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职业迁徙
个人简介
We are interested in understanding how developmental pathways are connected to adult tissue regeneration. We are investigating the Hippo, Wnt, and Bmp-signaling pathways for developmental and regenerative capabilities. Our goal is to obtain an in depth understanding of these pathways in order to develop ways to regenerate heart muscle and craniofacial bone. We first reported a role for the Hippo pathway in inhibiting cardiomyocyte proliferation to limit heart size during mammalian development. Our lab also observed that inactivation of Hippo in adult cardiomyocytes unleashes productive heart regeneration and promotes reversal of heart failure and that Hippo functions as a key regulator in cardiac fibroblasts and inflammatory responses. Our ongoing studies are aimed at translating this work into meaningful cardiac therapy approaches.
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论文共 284 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2024)
Yu-Jung Tseng, Yuki Kageyama,Rebecca L. Murdaugh,Ayumi Kitano,Jong Hwan Kim,Kevin A. Hoegenauer, Jonathan Tiessen, Mackenzie H. Smith,Hidetaka Uryu,Koichi Takahashi,James F. Martin,Md Abul Hassan Samee,
Nature Communicationsno. 1 (2024): 1-16
bioRxiv : the preprint server for biology (2024)
LIFE SCIENCE ALLIANCEno. 2 (2024)
Mashrur Ahmed Yafi, Md. Hasibul Husain Hisham, Francisco Grisanti,James F. Martin,Atif Rahman,Md. Abul Hassan Samee
Genome Biologyno. 1 (2024): 1-17
Rich Gang Li,Xiao Li,Yuka Morikawa, Francisco J. Grisanti-Canozo,Fansen Meng, Chang-Ru Tsai, Yi Zhao, Lin Liu,Jong Kim, Bing Xie, Elzbieta Klysik,Shijie Liu,
Shijie Liu, Kyoungmin Kim, Yaqi Gao,Seth Gammon,Lin Tan,Heinrich Taegtmeyer,Philip Lorenzi,David Piwnica-Worms,James F. Martin,Anja Karlstaedt
CIRCULATION (2023)
CIRCULATION RESEARCHno. Suppl_1 (2023)
crossref(2023)
Journal of molecular and cellular cardiology (2023): 100-101
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