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Understanding how the nervous system develops and generates complex behaviors is one of the great challenges facing biologists. My laboratory uses genetic and molecular approaches to study the nervous system of the nematode C. elegans . The worms entire nervous system has just 302 neurons whose detailed structure and interconnections have been determined by electron microscopy. Studies in the lab focus on three behaviors. The first is the formation of the specialized dauer larva, which is regulated by environmental factors that are sensed and interpreted by the nervous system. We have analyzed interactions among many genes that regulate dauer formation and have shown that they function in specific and orderly, though complex, pathways.
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论文共 174 篇作者统计合作学者相似作者
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Journal of the American Society of Echocardiography (2024)
Ramsey M. Wehbe, Aggelos K. Katsaggleos,Kristian J. Hammond,Ha Hong,Faraz Ahmad,David Ouyang,Sanjiv J. Shah,Patrick M. McCarthy,James D. Thomas
JAMA Cardiologyno. 11 (2023): 1089-1089
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Sarah Nisivaco,Patrick M. McCarthy,Jane Kruse, Aline Moreira Brandão André,Manyun Zhao,James D. Thomas
The Journal of Thoracic and Cardiovascular Surgery (2023)
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Journal of the American Society of Echocardiographyno. 3 (2023): 373-374
James D. Thomas, O. Madalina Petrescu, Soundos K. Moualla, Mike Dobbles, J. Clay Hays,Evelio Rodriguez,Glenn R. Barnhart
Intelligence-Based Medicine (2022): 100059
Soundos K. Moualla,Patrick M. McCarthy,James D. Thomas, Mike Dobbles, O. Madalina Petrescu, Torrey Loper,Glenn R. Barnhart,J. Matthew Brennan
Intelligence-Based Medicine (2022): 100062
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