基本信息
浏览量:72
职业迁徙
个人简介
I am a clinician scientist with a specialist interest in haemopoietic stem cell transplantation, genome editing, genomics and bioinformatics. I studied medicine at Oxford University before going on to complete specialist training in haematology and intensive care medicine in London. At present I have an MRC Clinician Scientist Fellowship and I am setting up a group at the Weatherall Institute of Molecular Medicine. In addition, I am an honorary consultant haematologist with the allogeneic transplant service in Oxford.
My research focuses on developing novel next generation sequencing-based methods for interrogating how the genome functions and leveraging this to develop methods of genome editing bone marrow derived stem cells. I have a particular interest in developing methods that allow the physical structure of DNA in the nucleus to be defined. With Jim Hughes and Doug Higgs I developed the Capture-C method. This technique lead to insights into how genes are controlled and I was awarded the RDM Graduate Prize for this project. I am also interested in using genome editing of bone marrow derived stem cells to treat disease. In particular, I am using my previous expertise in bioinformatics to and high throughput sequencing to develop new ways of defining off target effects from genome editing.
My research focuses on developing novel next generation sequencing-based methods for interrogating how the genome functions and leveraging this to develop methods of genome editing bone marrow derived stem cells. I have a particular interest in developing methods that allow the physical structure of DNA in the nucleus to be defined. With Jim Hughes and Doug Higgs I developed the Capture-C method. This technique lead to insights into how genes are controlled and I was awarded the RDM Graduate Prize for this project. I am also interested in using genome editing of bone marrow derived stem cells to treat disease. In particular, I am using my previous expertise in bioinformatics to and high throughput sequencing to develop new ways of defining off target effects from genome editing.
研究兴趣
论文共 67 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Anna Appios,James Davies,Sofia Sirvent,Stephen Henderson,Sébastien Trzebanski,Johannes Schroth, Morven L. Law, Inês Boal Carvalho, Howard Yuan-Hao Kan, Shreya Lovlekar, Christina Major,Andres Vallejo,
biorxiv(2024)
Sunniyat Rahman, Gianna Bloye,Nadine Farah,Jonas Demeulemeester,Joana R. Costa, David O'Connor,Rachael Pocock, Adam Turna, Lingyi Wang,SooWah Lee,Adele K. Fielding,Juliette Roels,
biorxiv(2024)
Cell Stem Cellno. 5 (2023): 722-740.e11
The EMBO journal (2023)
引用0浏览0WOS引用
0
0
bioRxiv : the preprint server for biology (2023)
British Journal of Dermatologyno. Supplement_4 (2023)
引用0浏览0引用
0
0
The EMBO Journalno. 20 (2023)
引用2浏览0引用
2
0
Xiaosai Yao,Jing Tan, Kevin Junliang Lim,Joanna Koh,Wen Fong Ooi,Zhimei Li,Dachuan Huang,Manjie Xing, Yang Sun Chan, James Zhengzhong Qu,Su Ting Tay, Giovani Wijaya,
crossref(2023)
Nicholas T. Crump,Alastair L. Smith,Laura Godfrey, Ana M. Dopico-Fernandez,Nicholas Denny,Joe R. Harman,Joseph C. Hamley,Nicole E. Jackson, Catherine Chahrour,Simone Riva,Siobhan Rice,Jaehoon Kim,
Blood (2023): 40
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn