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The major discovery is that genetic variants of PCSK9 – loss of function variants – have improved survival from septic shock and that in murine models, PCSK9 knock-outs and antibodies to PCSK9 also have improved survival from septic shock. This important discovery has potentially important therapeutic implications in septic shock; we are now investigating the potential efficacy and safety of PCSK9 inhibitor(s) in septic shock.
Affiliations
Member, Editorial Board, Journal of Innate Immunity, 2008 – present
Member, Editorial Board, American Journal of Respiratory and Critical Care Medicine, 2012 – present
Member, Editorial Board, Annals of Intensive Care, 2012 – present
Member, Editorial Board, Intensive Care Medicine, 2015 – present
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THORAXno. 2 (2024): 101-103
CRITICAL CARE MEDICINEno. 3 (2024): 509-512
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Canadian Journal of General Internal Medicineno. 2 (2023): 43-48
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CMAJ openno. 4 (2023): E672-E683
Pratik Sinha,V Eric Kerchberger,Andrew Willmore, Julia Chambers,Hanjing Zhuo,Jason Abbott,Chayse Jones,Nancy Wickersham, Nelson Wu,Lucile Neyton,Charles R Langelier,Eran Mick,
The Lancet. Respiratory medicineno. 11 (2023): 965-974
PloS oneno. 6 (2023): e0286588-e0286588
Journal of proteome researchno. 1 (2023): 52-70
NEJM catalyst innovations in care deliveryno. 9 (2023)
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Karen Tran,Alyson W. Wong, Zachary Schwartz,Jesse Greiner,Peter Birks, Sharry Kahlon,Christopher Carlsten, Christopher J. Ryerson,Selena Shao, Lee Er,James A. Russell,Adeera Levin
Canadian Journal of General Internal Medicineno. 2 (2023): 18-30
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