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职业迁徙
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Research Description
Our laboratory studies gene expression in multicellular eukaryotes on both the specific gene and chromosomal levels using Drosophila and maize as experimental organisms. We are interested in the mechanisms involved, how the two levels are interconnected and how they evolve.
A longstanding topic of investigation involves understanding the balance of gene regulatory mechanisms. Our results indicate that changing the stoichiometry of individual components of regulatory complexes affects target gene expression, which is manifested in chromosomal dosage series. The most common such dosage effect is an inverse correlation between the dosage of a chromosomal segment or individual regulator and the amount of target gene expression. This “inverse dosage” effect is likely to contribute to the molecular basis of aneuploid syndromes and when a regulatory dosage change is combined on the same chromosomal segment as a target gene, the target will exhibit dosage compensation. This type of dosage effect appears to be responsible for X chromosomal dosage compensation in Drosophila and potentially other species.
Our laboratory studies gene expression in multicellular eukaryotes on both the specific gene and chromosomal levels using Drosophila and maize as experimental organisms. We are interested in the mechanisms involved, how the two levels are interconnected and how they evolve.
A longstanding topic of investigation involves understanding the balance of gene regulatory mechanisms. Our results indicate that changing the stoichiometry of individual components of regulatory complexes affects target gene expression, which is manifested in chromosomal dosage series. The most common such dosage effect is an inverse correlation between the dosage of a chromosomal segment or individual regulator and the amount of target gene expression. This “inverse dosage” effect is likely to contribute to the molecular basis of aneuploid syndromes and when a regulatory dosage change is combined on the same chromosomal segment as a target gene, the target will exhibit dosage compensation. This type of dosage effect appears to be responsible for X chromosomal dosage compensation in Drosophila and potentially other species.
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Nicolas Blavet,Hua Yang,Handong Su, Pavel Solanský,Ryan N Douglas,Miroslava Karafiátová, Lucie Šimková,Jing Zhang,Yalin Liu,Jie Hou,Xiaowen Shi,Chen Chen,
Plant Biotechnology Journalno. 11 (2018): 1848-1857
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R. Kelly Dawe, Elizabeth G. Lowry,Jonathan I. Gent,Michelle C. Stitzer, Kyle W. Swentowsky,David M. Higgins,Jeffrey Ross-Ibarra,Jason G. Wallace, Lisa B. Kanizay,Magdy Alabady,Weihong Qiu,Kuo-Fu Tseng,
Current Protocols in Plant Biologypp.124-134, (2017)
MAIZE KERNEL DEVELOPMENT (2017)
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