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Jack Strominger’s lab specializes in the structure and function of human histocompatibility proteins and their roles in disease.
Research in the lab centers on three projects. They study the role of MHC proteins and of products of other disease susceptibility genes in human autoimmunity, including multiple sclerosis, diabetes, pemphigus vulgaris, and ankylosing spondylitis. They investigate activating and inhibitory immunological synapses in human natural killer cells: how they are formed and how they function, particularly in relation to lipid rafts. They also explore uterine decidual lymphocytes and their roles in the immunobiology of pregnancy.
The focus of the work in the lab is now understanding tolerance and immunity at the maternal-fetal interface.
Research in the lab centers on three projects. They study the role of MHC proteins and of products of other disease susceptibility genes in human autoimmunity, including multiple sclerosis, diabetes, pemphigus vulgaris, and ankylosing spondylitis. They investigate activating and inhibitory immunological synapses in human natural killer cells: how they are formed and how they function, particularly in relation to lipid rafts. They also explore uterine decidual lymphocytes and their roles in the immunobiology of pregnancy.
The focus of the work in the lab is now understanding tolerance and immunity at the maternal-fetal interface.
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Immunology and Cell Biologyno. 5 (2016): 419-420
Cancer Researchno. 9 (2008): 3204-3213
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