基本信息
浏览量:2
职业迁徙
个人简介
I am a Principle Investigator and Wellcome Trust/Royal Society Sir Henry Dale Fellow.
The central focus of my lab lies in the development of novel and non-invasive MRI techniques to assess brain physiology with application of these methods to address key questions in neurology and neuroscience. Inspired by the recent descriptions of the glymphatic system by Dr. Nedergaard and colleagues, we have worked to develop the first non-invasive techniques to image cerebrospinal fluid-mediated brain clearance pathways, working towards improved diagnostic and treatment strategies for Alzheimer’s disease. We have since developed two novel and non-invasive MRI techniques that assess specific components of brain fluid movement implicated in the early stages of AD development: i) imaging of perivascular fluid movement [Harrison et al., 2018]; ii) imaging of aquaporin-4 mediated blood brain barrier permeability to water [Ohene et al., 2019; Ohene et al., 2020]. In addition, most recently, we have designed and validated the first non-invasive technique to assess blood-cerebrospinal fluid barrier (BCSFB) function [Evans et al., 2020].
I am based at the UCL Centre for Advanced Biomedical Imaging, which houses 11 different advanced imaging modalities. By working in a pre-clinical setting, this allows me to acquire precise data in highly experimentally controlled conditions with validation through comparison to invasive and ex-vivo measurements.
Academic Background
The central focus of my lab lies in the development of novel and non-invasive MRI techniques to assess brain physiology with application of these methods to address key questions in neurology and neuroscience. Inspired by the recent descriptions of the glymphatic system by Dr. Nedergaard and colleagues, we have worked to develop the first non-invasive techniques to image cerebrospinal fluid-mediated brain clearance pathways, working towards improved diagnostic and treatment strategies for Alzheimer’s disease. We have since developed two novel and non-invasive MRI techniques that assess specific components of brain fluid movement implicated in the early stages of AD development: i) imaging of perivascular fluid movement [Harrison et al., 2018]; ii) imaging of aquaporin-4 mediated blood brain barrier permeability to water [Ohene et al., 2019; Ohene et al., 2020]. In addition, most recently, we have designed and validated the first non-invasive technique to assess blood-cerebrospinal fluid barrier (BCSFB) function [Evans et al., 2020].
I am based at the UCL Centre for Advanced Biomedical Imaging, which houses 11 different advanced imaging modalities. By working in a pre-clinical setting, this allows me to acquire precise data in highly experimentally controlled conditions with validation through comparison to invasive and ex-vivo measurements.
Academic Background
研究兴趣
论文共 89 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
JOURNAL OF MAGNETIC RESONANCE IMAGINGno. 2 (2024): 431-449
Phoebe G. Evans, Maria Sajic,Yichao Yu,Ian F. Harrison,Patrick S. Hosford, Ken J. Smith,Mark F. Lythgoe,Daniel J. Stuckey,Jack A. Wells
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2023)
引用0浏览0WOS引用
0
0
Patrick S Hosford,Jack A Wells,Shereen Nizari,Isabel N Christie,Shefeeq M Theparambil, Pablo A Castro,Anna Hadjihambi,L Felipe Barros,Iván Ruminot, Mark F Lythgoe,Alexander V Gourine
Advanced Scienceno. 6 (2022)
Basic science (2022)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn