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Stout notes that most of all, Fee was absorbed in understanding the cytochrome ba3 oxidase from Thermus thermophilus, “which represented to him the ultimate problem in bioenergetics. Jim’s approach to understanding ba3 was total; he wanted to understand electron transfer, oxygen diffusion, proton translocation, and most critically, the chemical basis of the vectorial proton production concomitant with reduction of oxygen to water.” In pursuit of this understanding, Fee forged a number of collaborations, including with the Scripps Research laboratories of Lou Noodleman and Arthur Olson.
The author of more than 150 papers in scholarly journals, Fee was awarded honors including the Harry J. Duell Award from the University of Southern California and a National Science Foundation Fellowship at the University of Göteborg, Sweden. He was a member of the American Association for the Advancement of Science, American Chemical Society, and American Society of Biological Chemists.
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