基本信息
浏览量:4
职业迁徙
个人简介
Our laboratory is focused upon the molecular mechanisms whereby vitamin D, the sex steroids, and other systemic hormones regulate the production as well as cellular activity of bone-forming osteoblasts and bone-resorbing osteoclasts. These two cell types act in concert both to maintain skeletal integrity and to provide vertebrate organisms with minerals such as calcium and phosphorus, and their coordinated and balanced actions are essential to these processes. We seek a detailed understanding of the functional role of each of these hormones in normal skeletal biology as well as their potentially therapeutic role in such diseases as arthritis, osteoporosis, and osteolytic diseases associated with metastatic breast and prostate cancer.
A long-term area of interest has been in the actions of vitamin D. Vitamin D is known to play an important role in skeletal homeostasis, functioning both to stimulate bone formation as well as bone resorption. We have shown that these actions are mediated by a specific receptor that is localized to the nucleus of target cells and which functions as a transcription factor following activation by its hormonal vitamin D ligand. Our research led to the molecular cloning of this factor and elucidation of its regulation and mechanism of action. Current studies seek to extend our knowledge of how this interesting receptor molecule functions to regulate transcription and to identify vitamin D regulated genes that mediate osteoblast and osteoclast function.
A more recent area of interest is in the molecular actions of the sex steroids. Aside from their reproductive roles, the sex steroids estrogen and androgen exert bone protective activities. As a consequence, loss of these hormones during the aging process or following menopause leads to a dramatic loss of bone mineral and an increased risk of fracture. We have shown that both estrogens and androgens function through their nuclear receptors to limit the production of the bone resorbing osteoclasts through a direct action that suppresses osteoclast differentiation. Current studies are focused on understanding both this cellular differentiation process as well as the molecular mechanisms utilized by estrogen to block this important event. These studies involve the use of DNA microarrays to identify the regulatory genes that participate in the differentiation process. Our studies are likely to lead to a better understanding of the pathways that regulate osteoclast formation and to the identification of new estrogenic species with greater bone protective properties.
研究兴趣
论文共 161 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Elsevier eBookspp.213-228, (2024)
引用0浏览0引用
0
0
Elsevier eBookspp.139-154, (2024)
引用0浏览0引用
0
0
The Journal of Steroid Biochemistry and Molecular Biology (2023): 106352-106352
引用0浏览0WOS引用
0
0
Sung-Hee Yoon,Mark B. Meyer, Carlos Arevalo,Murat Tekguc,Chengcheng Zhang,Jialiang S. Wang,Christian D. Castro Andrade, Katelyn Strauss,Tadatoshi Sato,Nancy A. Benkusky,Seong Min Lee,Rebecca Berdeaux,
JOURNAL OF BONE AND MINERAL RESEARCH (2023): 226-226
引用0浏览0引用
0
0
The Journal of steroid biochemistry and molecular biology (2023): 106252-106252
JOURNAL OF BONE AND MINERAL RESEARCH (2023): 222-222
引用0浏览0引用
0
0
The Journal of Steroid Biochemistry and Molecular Biology (2023): 106335-106335
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn