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职业迁徙
个人简介
Research Interest
Macromolecular Structure and Function
Structural and functional studies of protein targets related to infectious diseases (host-pathogen interactions) and cancers
Research Focus
Proteins are important biological macromolecules playing vital and integral roles in all living systems. Proteins are implicated as causes of many diseases. X-ray crystallography enables us to determine three-dimensional structures of proteins, and thus to understand their functional roles and contributions to diseases. It is important to study proteins that play key roles in diseases. This can be achieved by structural and structure based functional both in vitro (mutagenesis and biophysical / biochemical / biological) and in vivo studies.
My laboratory focuses on a number of host and pathogen proteins that play important roles in infectious diseases. The project encompasses studies of molecular mechanisms of bacterial and viral pathogenesis in the context of disease processes. To this end, we are investigating several targets to understand the biological question on how virulence factors of Gram-negative bacteria initiate the infection process. To address this question we study the type III secretion system (T3SS) and type VI secretion systems (T6SS). Similarly in the viral pathogenesis, we are investigating the mechanism of host interaction and neutralization of hepatitis E virus (HEV).
We are also studying the structural basis for the mechanism of action of a number of cancer related proteins and their interactions to understand the key steps in the signal transduction pathways.
The long-term goal of our group is to illuminate outstanding challenges in the area of infectious diseases through host-pathogen interactions and cancers to provide new avenues for addressing them towards drug design and development.
Macromolecular Structure and Function
Structural and functional studies of protein targets related to infectious diseases (host-pathogen interactions) and cancers
Research Focus
Proteins are important biological macromolecules playing vital and integral roles in all living systems. Proteins are implicated as causes of many diseases. X-ray crystallography enables us to determine three-dimensional structures of proteins, and thus to understand their functional roles and contributions to diseases. It is important to study proteins that play key roles in diseases. This can be achieved by structural and structure based functional both in vitro (mutagenesis and biophysical / biochemical / biological) and in vivo studies.
My laboratory focuses on a number of host and pathogen proteins that play important roles in infectious diseases. The project encompasses studies of molecular mechanisms of bacterial and viral pathogenesis in the context of disease processes. To this end, we are investigating several targets to understand the biological question on how virulence factors of Gram-negative bacteria initiate the infection process. To address this question we study the type III secretion system (T3SS) and type VI secretion systems (T6SS). Similarly in the viral pathogenesis, we are investigating the mechanism of host interaction and neutralization of hepatitis E virus (HEV).
We are also studying the structural basis for the mechanism of action of a number of cancer related proteins and their interactions to understand the key steps in the signal transduction pathways.
The long-term goal of our group is to illuminate outstanding challenges in the area of infectious diseases through host-pathogen interactions and cancers to provide new avenues for addressing them towards drug design and development.
研究兴趣
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Su Ning Loh, Ian Russell Anthony,Edem Gavor, Xin Shan Lim,R Manjunatha Kini,Yu Keung Mok,J Sivaraman
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