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We are primarily interested in the roles that cells of the innate immune system play in coordinating inflammation and how they contribute to activation of adaptive immunity via the production of cytokines. Innate immune cells are able to recognize specific components of pathogens – referred to as pathogen associated molecular patterns or PAMPs. Several groups of receptors for PAMPs have been described, including Toll like receptors, C-type lectins and NOD-like proteins. These receptors trigger the activation of several intracellular signaling pathways, including the mitogen activated protein kinase (MAPK), NFkappaB and TBK1/IRF systems leading to the transcription and production of both pro- and anti-inflammatory cytokines. Our main focus is to understand the roles these intracellular signaling cascades play in both the initial inflammatory response and in the ability of innate immune cells, particularly macrophages and dendritic cells, to activate the adaptive immune system. Finally we are interested in the ways in which intracellular signaling in innate immune cells controls the induction of anti-inflammatory and pro-resolution factors in order to deactivate the immune system.
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论文共 206 篇作者统计合作学者相似作者
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
Frontiers in cardiovascular medicine (2023): 1125687
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John D. O'Neil, Oliwia O. Bolimowska,Sally A. Clayton,Tina Tang,Kalbinder K. Daley,Samuel Lara-Reyna,Jordan Warner,Claire S. Martin,Rahul Y. Mahida,Rowan S. Hardy,J. Simon C. Arthur,Andrew R. Clark
Frontiers in Immunology (2023): 1190261-1190261
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STAR Protocolsno. 4 (2022): 101725-101725
CELLSno. 4 (2022): 604
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