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The physiological effects of cancer are a manifestation of the genetic abnormalities that cause the disease. While much progress has been made in the understanding of such genetic perturbations, scientists still struggle to effectively identify, understand, and treat cancer-causing mutations. This is due to the fast-paced evolution of the disease, and the accumulation of novel mutations that permit cell survival even in the harsh environment created by a therapeutic. CRISPR is a gene-editing technology that couples the elegance of base complementarity with the enzymatic activity of a DNA nuclease in order to introduce mutations into target loci. CRISPR technologies help advance our understanding of the genetic perturbations that contribute to cancer maintenance.
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论文共 126 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2024)
Zhen Zhang,Amy E. Baxter, Diqiu Ren,Kunhua Qin, Zeyu Chen, Sierra M. Collins,Hua Huang, Chad A. Komar, Peter F. Bailer, Jared B. Parker,Gerd A. Blobel, Rahul M. Kohli,
Nature Biotechnologyno. 2 (2024): 305-315
Cancer Researchno. 6_Supplement (2024): 1689-1689
Journal of Biological Chemistryno. 3 (2024)
Kiara N. Berrios,Aleksia Barka, Jasleen Gill, Juan C. Serrano, Peter F. Bailer, Jared B. Parker,Niklaus H. Evitt,Kiran S. Gajula,Junwei Shi,Rahul M. Kohli
NUCLEIC ACIDS RESEARCHno. 4 (2024): 2078-2090
Bloodno. 19 (2024): 1980-1991
Amy E Baxter,Hua Huang,Josephine R Giles,Zeyu Chen,Jennifer E Wu,Sydney Drury, Katherine Dalton,Simone L Park, Leonel Torres, Brandon W Simone,Max Klapholz,Shin Foong Ngiow,
Immunityno. 6 (2023): 1320-1340.e10
RADIOTHERAPY AND ONCOLOGY (2023): 109813-109813
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