基本信息
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职业迁徙
个人简介
Sphingosine-1-phosphate (S1P) is a bioactive lipid that plays important roles in development, vascular biology, immune cell trafficking, carcinogenesis and other physiological processes. S1P mediates its actions primarily by signaling through a family of G protein-coupled receptors. Our research group is investigating the role of S1P metabolism and signaling in development and disease using cellular and animal models, translational approaches and metabolomics profiling. Our recent findings demonstrate that defects in S1P metabolism underlie a novel childhood syndrome called sphingosine phosphate lyase insufficiency syndrome (SPLIS), which is characterized by defects of kidney, adrenal gland, neurological system, skin and immune system. We are now developing several therapeutic approaches to the treatment of SPLIS including gene therapy and cofactor supplementation.
Interests
sphingolipids, pediatric cancer, nephrotic syndrome, sphingosine-1-phosphate signaling and metabolism, inflammatory bowel disease, colon cancer, inborn errors of metabolism, sphingosine phosphate lyase insufficiency syndrome
研究兴趣
论文共 178 篇作者统计合作学者相似作者
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Joni C. Sedillo, Chansonette Badduke,Steven J. Schrodi, Vinod Scaria, Onur Emre Onat,Majid Alfadhel,Carole Ober,William Wentworth-Sheilds,Robert D. Steiner,Julie D. Saba
Genetics in Medicine Open (2024): 100840
Babak Oskouian,Joanna Y. Lee,Shahab Asgharzadeh, Ranjha Khan,Meng Zhang, Julia R. Weisbrod, Youn-Jeong Choi, Latika Puri, Ana E. Aguilar,Piming Zhao,Julie D. Saba
Oncogeneno. 16 (2024): 1-11
Aritra Bhattacharyya, Ranjha Khan,Joanna Y Lee, Gizachew Tassew,Babak Oskouian,Maria L Allende,Richard L Proia,Xiaoyang Yin, Javier G Ortega,Mallar Bhattacharya,Julie D Saba
The Journal of pathologyno. 1 (2024): 22-31
Henrik Fyrst,Babak Oskouian, Padmavathi Bandhuvula,Yaqiong Gong, Hoe Sup Byun, Robert Bittman, Andrew R. Lee,Julie D. Saba
crossref(2023)
Henrik Fyrst,Babak Oskouian, Padmavathi Bandhuvula,Yaqiong Gong, Hoe Sup Byun, Robert Bittman,Andrew R. Lee,Julie D. Saba
crossref(2023)
International Journal of Molecular Sciencesno. 21 (2023): 15560-15560
G. Pampalone,C. Costantini,M. Pariano,E. Camaioni, L. Macchioni,R. Galarini,F. Paoletti,T. Zelante, E. Costanzi, M. Davidescu,C. Stincardini, M. Bellet,
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Julie Saba,Piming Zhao,Gizachew Tassew,Joanna Lee,Babak Oskouian, Denise Munoz, Jeffrey B. Hodgin,Gordon L. Watson, Felicia Tang,Jen-Yeu Wang,Jinghui Luo,Yingbao Yang,
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