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Our laboratory has been interested in the molecular mechanisms of cellular differentiation and gene expression for a long time. To address the problem, we are studying a cell line of mouse fibroblasts (preadipocytes) that undergo differentiation to fat cells (adipocytes) in cell culture. During the differentiation process the levels of expression of a large number of fat-specific genes increases in a coordinate fashion. One of these genes encodes SCD1. We are using molecular biology approaches to characterize the mechanisms that regulate the expression of the SCD genes during fat cell differentiation. We are also using genetic tools to knockdown the expression of the different SCD isoforms and assess their importance for [Role of SCDs in adipocyte differentiation and metabolism] normal adipocyte differentiation. Based upon the skin-related phenotypes observed in mice lacking SCD1 in the skin, we are also interested in the role of SCD in the differentiation of sebocytes, which are the major lipid producing cells of the skin. Our objective is to determine the molecular events that define the differentiation process in both adipocytes and sebocytes.
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Dylan Cootway,Mugagga Kalyesubula, Jacqueline Miller, Hailey Huff, Luke Lefers, Veronica Pegkou Christofi,Ethan Anderson,James Ntambi
Journal of Biological Chemistryno. 3 (2024)
Jacqueline Miller,Mugagga Kalyesubula, Dylan Cootway, Hailey Huff, Luke Lefers, Veronica Pegkou Christofi,Ethan Anderson,James Ntambi
Journal of Biological Chemistryno. 3 (2024)
Elsevier eBookspp.421-438, (2023)
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Elsevier eBookspp.67-97, (2023)
Mugagga Kalyesubula,Luke Lefers,Hailey Huff, Dylan Cootway, Jacqueline Miller, Gisela Geoghegan, Mainak Dutta,Judith Simcox,James Ntambi
Journal of Biological Chemistryno. 3 (2023): 103895-S476
biorxiv(2023)
Annual review of nutritionno. 1 (2023): 1-23
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