John A Lupisella - Bristol-Myers Squibb

基本信息

Career Trajectory

Bio

M.S. Cellular and Molecular Biology: Over 28 years experience in drug discovery; Primary expertise is in understanding the tissue-specific, developmental and hormonal signals that dictate gene expression in mammalian systems. Target class expertise in nuclear hormone receptors (RAR, RXR, VDR, AR, LXR, PPAR, FXR, GR) and GPCRs. Currently interested in GPCRs and mediators involved in the active resolution of inflammation.

Research Interests

Papers共 33 篇Author StatisticsCo-AuthorSimilar Experts

By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选

Formyl-peptide Receptor Type 2 Activation Mitigates Heart and Lung Damage in Inflammatory Arthritis

Andreas Margraf, Jianmin Chen, Marilena Christoforou,Pol Claria-Ribas, Ayda Henriques Schneider,Chiara Cecconello, Weifeng Bu, Paul R C Imbert, Thomas D Wright, Stefan Russo, Isobel A Blacksell,Duco S Koenis,Jesmond Dalli,John A Lupisella,Nicholas R Wurtz,Ricardo A Garcia,Dianne Cooper,Lucy V Norling,Mauro Perretti

EMBO molecular medicineno. 5 (2025): 1153-1183

Cited0Views0WOSBibtex

Discovery and Optimization of Aryl Piperidinone Ureas As Selective Formyl Peptide Receptor 2 Agonists

Nicholas R. Wurtz,Pravin S. Shirude,Daniel L. Cheney,John A. Lupisella, Amit Kumar Chattopadhyay,Vishweshwaraiah Baligar, Balaji Seshadri,Prakash Anjanappa,Andrew Viet,Meriah N. Valente,Mei-Yin Hsu, Mojgan Abousleiman,Sanket Sarodaya, Debarati M. Tagore,Shailesh Dudhgaonkar, Sivaprasad Putlur,Elizabeth A. Dierks,Jacek Ostrowski,Ruth R. Wexler,Ricardo Garcia,Ellen K. Kick

ACS Medicinal Chemistry Lettersno. 9 (2024): 1500-1505

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Formyl Peptide Receptor 2 and Heart Disease

John A. Lupisella, Pravin S. Shirude,Nicholas R. Wurtz,Ricardo A. Garcia

Seminars in immunology（2022）

Cited16Views0WOSBibtex

Molecular Mechanisms of Desensitization Underlying the Differential Effects of Formyl Peptide Receptor 2 Agonists on Cardiac Structure-Function Post Myocardial Infarction

R. Garcia,S. St-Onge,M. Carrier,E. Cook,T. Wang,C. Sum,G. Fernando,K. Apgar,R. Zhang,N. L. Carson,B. J. Snyder,J. A. Lupisella,N. R. Wurtz,M. Bouvier,M. Heroux

ACS Pharmacology & Translational Science（2022）

Cited5Views0WOSBibtex

Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists

Nicholas R. Wurtz,James A. Johnson,Andrew Viet,Pravin S. Shirude,Vishweshwaraiah Baligar, Sudhakara Madduri,Daniel L. Cheney,Hyunsoo Park,John A. Lupisella,Mei-Yin Hsu, Mojgan Abousleiman,Michael A. Galella,Darpandeep Aulakh,Elizabeth A. Dierks,Ricardo A. Garcia,Jacek Ostrowski,Ellen K. Kick,Ruth R. Wexler

ACS Medicinal Chemistry Letters（2022）

Cited2Views0WOSBibtex

2420Effects of a Selective Small-Molecule Formyl Peptide Receptor 2 Agonist on Post Myocardial Inflammation and Left Ventricular Structure-Function Relationships

R. A. Garcia,J. A. Lupisella,R. Zhang,N. L. Carson,Z. Wang,M. Y. Hsu,G. Fernando, C. S. Ryan, E. Dierks,Y. Asahina,Y. Kohno,N. R. Wurtz,J. Ostrowski,B. R. Ito,F. J. Villarreal

EUROPEAN HEART JOURNAL（2019）

Cited0Views0Bibtex

Preservation of Post-Infarction Cardiac Structure and Function Via Long-Term Oral Formyl Peptide Receptor Agonist Treatment

Ricardo A. Garcia,Bruce R. Ito,John A. Lupisella, Nancy A. Carson,Mei-Yin Hsu,Gayani Fernando,Madeleine Heroux,Michel Bouvier,Elizabeth Dierks,Ellen K. Kick,David A. Gordon,Jian Chen,Gabe Mintier,Marilyn Carrier,Stephane St-Onge, Himanshu Shah, Jordan Towne, Marcela Sotelo Bucardo,Xiuying Ma,Carol S. Ryan,Nicholas R. Wurtz,Jacek Ostrowski,Francisco J. Villarreal

JACC Basic to Translational Science（2019）

Cited43Views0WOSBibtex

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