Jian Guo Wen(文建国)

Qualified and awarded MD from Henan Medical University, first PhD from Tonji Medical University China, second PhD from Medical Faculty of Aarhus University Denmark, and have been working in clinics and basic research area for incontinency and urodynamic study in children since 1984, became the member of International Children Continence Society(ICCS) in 2003, board member of (ICCS) in 2022,ICS Children Committee Member in 2012 (to 2018) and Urodynamic Committee Member（2013-2019，2022-present）, Director of School of Paediatric Voiding Dysfunction and Transitional Urology of ICS (2017-2021), Co-Editor of Journal of Continence of ICS; Vice-Chair of Scientific Committee, Asia-Pacific Association of Pediatric Urologists (APAPU)(2018--present). Honorary professor of Pediatric Urology of Faculty of Health of Aarhus University Denmark since 2014. Chair of Children’s Urodynamic and Pelvic Floor Group of Pediatric Surgery of Chinese Medical Association; Vice-Chairman of Chinese Pediatric Surgeon Association (2016-2021). 7. Deputy Editor of Chinese Journal of Clinical Pediatric Surgery (2022-present). Specialty: Pediatric Urology/Urology, Urodynamics and Incontinence More than 600 research papers have been published either in Chinese or English. (part of Publication) 1. A Study of Urodynamic Parameters at Different Bladder Filling Stages for Predicting Upper Urinary Tract Dilatation. Int Neurourol J. 2022;26(1):52-59. doi: 10.5213/inj.2142244.122. 2. Serum complement factor B is associated with disease activity and progression of idiopathic membranous nephropathy concomitant with IgA nephropathy. Int Urol Nephrol. 2022;54(6):1287-1294. doi: 10.1007/s11255-021-02997-2. 3. Activation of the TGF-β1/Smads/α-SMA pathway is related to histological and functional changes in children with neurogenic bladder. Sci Rep. 2022 ;12(1):9285. doi: 10.1038/s41598-022-13470-0. 4. Renal Megalin mRNA Downregulation Is Associated with CKD Progression in IgA Nephropathy. Am J Nephrol. 2022;53(6):481-489. doi: 10.1159/000524929. 5. ICAM-1 related long noncoding RNA is associated with progression of IgA nephropathy and fibrotic changes in proximal tubular cells. Sci Rep. 2022 ;12(1):9645. doi: 10.1038/s41598-022-13521-6. 6. Exosomes from human urine-derived stem cells carry NRF1 to alleviate bladder fibrosis via regulating miR-301b-3p/TGFβR1 pathway. Mol Cell Biochem. 2022 . doi: 10.1007/s11010-022-04484-3. Epub ahead of print. 7. Ultrasound manifestations and clinical features of nonpalpable testis in children. Sci Rep. 2022;12(1):12245. doi: 10.1038/s41598-022-16230-2. 8. Erythropoietin prevented the decreased expression of aquaporin1-3 in ureteral obstructive kidneys in juvenile rats. Pediatr Res. 2022 . doi: 10.1038/s41390-022-02224-3. 9. Alteration of N6-methyladenosine epitranscriptome profiles in bilateral ureteral obstruction-induced obstructive nephropathy in juvenile rats. Pediatr Res. 2022. doi: 10.1038/s41390-022-02228-z. 10. Video-urodynamics efficacy of sacral neuromodulation for neurogenic bladder guided by three-dimensional imaging CT and C-arm fluoroscopy: a single-center prospective study. Sci Rep. 2022;12(1):16306. doi: 10.1038/s41598-022-20731-5. 11. Efficacy and Safety of Sacral Neuromodulation by Converting Constant Frequency Stimulation Into Variable Frequency Stimulation in Patients With Detrusor Overactivity and Impaired Contractility: A Single-Center Prospective Study. Neuromodulation. 2022:S1094-7159(22)00756-5. doi: 10.1016/j.neurom.2022.07.002. 12. Serum complement factor B is associated with disease activity and progression of idiopathic membranous nephropathy concomitant with IgA nephropathy [published online ahead of print, 2021 Sep 28]. Int Urol Nephrol. 2021;10.1007/s11255-021-02997-2. 13. Losartan prevents bladder fibrosis and protects renal function in rat with neurogenic paralysis bladder. Neurourol Urodyn. 2021;40(1):137-146. 14. Histamine H3 Receptor Signaling Regulates the NLRP3 Inflammasome Activation in C2C12 Myocyte During Myogenic Differentiation. Front Pharmacol. 2021;12:599393. doi: 10.3389/fphar.2021.599393. 15. METTL3/N6-methyladenosine/ miR-21-5p promotes obstructive renal fibrosis by regulating inflammation through SPRY1/ERK/NF-κB pathway activation. J Cell Mol Med. 2021 ;25(16):7660-7674. doi: 10.1111/jcmm.16603. 16. Delayed elimination communication on the prevalence of children's bladder and bowel dysfunction. Sci Rep. 2021;11(1):12366. doi: 10.1038/s41598-021-91704-3. 17. Mechanism and Priority of Botulinum Neurotoxin A versus Sacral Neuromodulation for Refractory Overactive Bladder: A Review [published online ahead of print, 2021 Jun 15]. Urol Int. 2021;1-6. doi:10.1159/000515991 18. Prevalence, Risk Factors, and Psychological Effects of Primary Nocturnal Enuresis in Chinese Young Adults. Int Neurourol J. 2021 ;25(1):84-92. doi: 10.5213/inj.2040398.149.