基本信息
浏览量:78
职业迁徙
个人简介
My research interests are in the structure and function of proteins implicated in Parkinson’s disease, Parkin and PINK1 in particular. These proteins have been shown to mediate neuroprotection and mitochondrial maintenance through their enzymatic activities and post-translational modifications (PTMs): Parkin is an E3 ubiquitin ligase and PINK1 is a Ser/Thr kinase. My goals are to: 1) elucidate the composition and 3D structure of molecular complexes formed by Parkin and PINK1 on mitochondria, 2) develop novel therapies for PD based on these structures. My group will use the full range of structural biology tools available at McGill, such as X-ray crystallography, NMR spectroscopy, SAXS, electron microscopy and mass spectrometry, in order to obtain the most complete and highest resolution picture of complexes formed by PINK1 and Parkin. These structures will inform us on how these enzymes become active and modify their substrates, and will guide the development of novel pharmacological targets.
研究兴趣
论文共 130 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Mohamed A Eldeeb,Andrew N Bayne, Armaan Fallahi,Thomas Goiran,Emma J MacDougall,Andrea Soumbasis,Cornelia E Zorca, Jace-Jones Tabah,Rhalena A Thomas, Nathan Karpilovsky,Meghna Mathur,Thomas M Durcan,
Proceedings of the National Academy of Sciences of the United States of Americano. 10 (2024): e2313540121-e2313540121
medRxiv : the preprint server for health sciences (2024)
BRAINno. 3 (2024): 887-899
Shafqat Rasool, Tara Shomali, Luc Truong,Nathalie Croteau,Simon Veyron, Bernardo A Bustillos,Wolfdieter Springer,Fabienne C Fiesel,Jean-François Trempe
Scientific reportsno. 1 (2024): 7739-7739
Kalle Gehring,Véronique Sauvé, Eric Stefan,Nathalie Croteau,Thomas Goiran,Rayan Fakih, Nupur Bansal, Adelajda Hadzipasic, Jing Fang,Edward A Fon, Warren Hirst, Laura Silvian,
crossref(2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
引用0浏览0引用
0
0
Frontiers in neurology (2023): 1227084
引用0浏览0WOS引用
0
0
Bruce Huang,Nathalie Croteau, Isabella Pecora,Igor Stagljar,Sidong Huang,Jean-Francois Trempe,Morag Park
PROTEIN SCIENCEno. 12 (2023)
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn