基本信息
浏览量:223
职业迁徙
个人简介
Research Interests
antiviral agents; chronic hepatitis; chronic hepatitis c; hepatitis b; hepatitis b virus; hepatitis c; interferon-alpha
Research Narrative
Dr. Dienstag's primary research interest is in viralhepatitis. Among his contributionshave been basic-virologic, experimental animal-model, immunologic andimmunopathogenetic, genetic, epidemiologic, vaccination, and antiviral studiesof hepatitis A, B, C, and D viruses.
Dr. Dienstag's recent research efforts havefocused on antiviral therapy for chronic viral hepatitis. Dr. Dienstag has participated inclinical trials of interferon therapy for chronic hepatitis C; in combination with the nucleoside analog ribavirin; innaive, relapsing, and nonresponder patients; with different formulations ofstandard interferon; with long-acting, pegylated, preparations, and with directly acting antiviral agents (e.g., protease inhibitors).
Dr. Dienstag led one of 10 Clinical Centerteams nationwide in an an multiyear trial of protracted antiviral therapy forpatients refractory to treatment for chronic hepatitis C. This study, designated the HALT-C (Hepatitis Antiviral Long-term Treatment against Cirrhosis) Trial, was designed to test the hypothesis that long-terminterferon therapy, even in biochemical/virologic nonresponders to interferon,can limit histologic and clinical progression. The HALT-C Trial also included a series of ancillary studiesthat defined virologic alterations during protracted therapy and during thenatural progression of disease and provided a rich source of clinicalmaterial, which shed light on the process of fibrosis andhepatocarcinogenesis.
Dr. Dienstag was the leading United States academicclinical investigator in the development of lamivudine as the first approvedorally administered nucleoside analog for the treatment of chronic hepatitisB.
研究兴趣
论文共 366 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Academic Medicine (2022)
International journal of medical informatics (2021): 104562-104562
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn