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Our research focuses on Chemical Glycobiology, which involves using chemical synthesis and biochemistry to develop new chemical tools that enable the wider field to study the roles of carbohydrates in biology. Contrary to popular belief, carbohydrates are not simply energy sources. They play many essential roles in cell and organismal biology. Indeed, all cells from every kingdom of life are coated by carbohydrates that function to communicate the inner state of the cell to the outside world. Various different monosaccharide building blocks are known and these are linked together by enzymes to form chain-like structures known as glycans. These glycans are often found as part of conjugates with proteins and lipids and are displayed on the surface of cells where they are serve as ligands of proteins found on other cells. The glycan structures present within these glycoconjugates can be remodeled by enzymes that prune and sculpt these structures. These regulated glycan structures are being uncovered as critical factors in health and disease, playing roles in processes ranging from inflammation to cell signaling and on to organismal development. The field of glycoscience was recently identified by the National Academy of Sciences as a frontier area of molecular sciences.
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论文共 270 篇作者统计合作学者相似作者
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Adriano Aguzzi,Jiang-An Yin,David J Vocadlo, Kathi Ging,Frick Lukas,Yanping Zhu,Johannes Schlachetzki,Pierre-Andre Gilormini, Xi Chen, Desiree Boeck, Tetiana Serdiuk, Ana Marques,
crossref(2024)
Darian Williams, Logan M Glasstetter, Tiffany T Jong,Abhijeet Kapoor,Sha Zhu, Yanping Zhu, Alexandra Gehrlein,David J Vocadlo,Ravi Jagasia,Juan J Marugan,Ellen Sidransky,Mark J Henderson,
bioRxiv : the preprint server for biology (2024)
Taiasean Wu, Joshua C Yu, Arundhati Suresh,Zachary J Gale-Day,Matthew G Alteen, Amanda S Woo,Zoe Millbern,Oleta T Johnson,Emma C Carroll,Carrie L Partch,Denis Fourches,Nelson R Vinueza,
Nature biotechnologypp.1-8, (2024)
Journal of Biological Chemistryno. 3 (2023): 104138-S614
Current Opinion in Chemical Biology (2023): 102403-102403
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Sandeep Bhosale,Matthew C. Deen,Cameron Proceviat, Andrew Hettle, Dana K. Winter,Jacob Brockerman, Marina Levene,Andrew J. Bennet,Claude Spino,Alisdair B. Boraston,David J. Vocadlo
ACS chemical biologyno. 8 (2023): 1730-1737
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