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From 1972 to the present research efforts have focused on mechanisms of oxidative injury and the role of antioxidants in blocking both normal and abnormal oxidative stress. A major emphasis has been on the role of extracellular superoxide dismutase as a regulator of inflammation and of intercellular signal transduction. This laboratory is developing small molecular weight catalytic antioxidants that can be used as drugs and as molecular probes to determine the role of free radicals in normal biology and in disease processes such as radiation-induced injury, stroke, diabetes, chronic lung disease and cancer.
In 2007, the COPDGene project was launched with Dr. Crapo and Dr. Ed Silverman as principal investigators. COPDGene is an NHLBI funded multi-institutional genetic epidemiology study which will carry out a genome-wide analysis of 10,500 subjects at risk for or with COPD to identify the primary genes that determine risk for developing COPD.
研究兴趣
论文共 783 篇作者统计合作学者相似作者
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American journal of respiratory and critical care medicineno. 4 (2023): 451-460
Antioxidants (Basel, Switzerland)no. 10 (2023): 1861-1861
E. S. Wan,S. Fortis,E. A. Regan,J. Hokanson, M. K. Han,R. Casaburi, B. J. Make,J. D. Crapo,D. L. Demeo, E. K. Silverman
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINEno. 7 (2023): 824-824
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Radiologyno. 4 (2023): e222786-e222786
medRxiv (Cold Spring Harbor Laboratory) (2023)
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International journal of molecular sciencesno. 8 (2023): 7362-7362
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