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The basic normal functioning of a cell is the consequence of a delicately balanced regulation of various cellular activities. My laboratory is interested in elucidating the molecular mechanisms of regulation, in particular, the ground rules employed in recognizing specific targets and transmitting of signals among these macromolecular components. These ground rules are embedded universally in the coupling between two linkage schemes. These schemes include the linkage among multiple thermodynamic parameters governing the biological functions and the intra- and inter-macromolecular networks of communication. There are three biological systems being investigated.
E .coli CAMP Receptor Protein (CRP)
Mechanism for the Evasion of Antibody Neutralization in Flaviviruses
Mammalian Pyruvate Kinase
E .coli CAMP Receptor Protein (CRP)
Mechanism for the Evasion of Antibody Neutralization in Flaviviruses
Mammalian Pyruvate Kinase
研究兴趣
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Allosteric Enzymespp.231-254, (2020)
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D-Core
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