Professor Chan is a clinician scientist committed to translate evidence to practice and develop novel solutions for unmet needs. In the early 1990s, motivated by the observation of high prevalence of young-onset type 2 diabetes and renal disease, she set up the Hong Kong Diabetes Registry and multiple cohorts to define the epidemiology of diabetes in Chinese populations. These prospective cohorts have laid the foundation for an overarching program to use a multiomic approach to discover genetic variants of diabetes and its complications for personalized care. She is currently a member of an NIH funded Global Consortium to discover causal genes in type 2 diabetes in a multi-ethnic population.