My research involves several aspects of genetics with special emphasis on cancer genetics of bone and soft tissue tumors. Over the years, we have identified a number of tumor specific chromosomal abnormalities, fusion transcripts, and/or genomic imbalances/mutations for both benign and malignant bone and soft tissue tumors as well as other solid tumors such as brain and kidney. These genetic abnormalities are important diagnostically and prognostically, as well as defining treatment strategies to include novel therapeutic targets. These data have also contributed significantly to our understanding of the histopathogenesis of many of these neoplasms..