Isabelle G. Tobey - Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard

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论文共 11 篇作者统计合作学者相似作者

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An AAV Capsid Reprogrammed to Bind Human Transferrin Receptor Mediates Brain-Wide Gene Delivery

Qin Huang,Ken Y. Chan,Jason Wu, Nuria R. Botticello-Romero,Qingxia Zheng, Shan Lou,Casey Keyes, Alexander Svanbergsson,Jencilin Johnston,Allan Mills, Chin-Yen Lin,Pamela P. Brauer,Gabrielle Clouse,Simon Pacouret, John W. Harvey,Thomas Beddow, Jenna K. Hurley,Isabelle G. Tobey,Megan Powell,Albert T. Chen,Andrew J. Barry,Fatma-Elzahraa Eid,Yujia A. Chan,Benjamin E. Deverman

SCIENCEno. 6701 (2024): 1220-1227

引用17浏览0WOSSCIENCE引用

Second Generation AAV Capsids Reprogrammed to Bind Human Transferrin Receptor Are Targeted to the Brain and De-Targeted from the Liver in Human TFRC Knock-In Mice

Ken Y. Chan,Qin Huang, Shan Lou,Casey Keyes,Jason Wu, Nuria R. Botticello-Romero,Qingxia Zheng, Chin-Yen Lin,Jencilin Johnston,Allan Mills,Pamela Brauer,Gabrielle Clouse,Simon Pacouret, John W. Harvey,Thomas Beddow, Jenna K. Hurley,Isabelle G. Tobey,Megan Powell, Catherine P. Pirtle,Albert Chen,Andrew J. Barry,Fatma-Elzahraa Eid,Yujia A. Chan,Benjamin E. Deverman

MOLECULAR THERAPYno. 4 (2024): 65-65

引用0浏览0引用

Systematic Multi-Trait AAV Capsid Engineering for Efficient Gene Delivery

Fatma-Elzahraa Eid,Albert T. Chen,Ken Y. Chan,Qin Huang,Qingxia Zheng,Isabelle G. Tobey,Simon Pacouret,Pamela P. Brauer,Casey Keyes,Megan Powell,Jencilin Johnston,Binhui Zhao,Kasper Lage,Alice F. Tarantal,Yujia A. Chan,Benjamin E. Deverman

NATURE COMMUNICATIONSno. 1 (2024)

引用5浏览0WOSNATURE引用

The Machine Learning-Guided Fit4Function Platform Quantitatively Profiles the Biodistribution of Peptide-Modified AAV Capsids after a Single Round of Screening in Macaque

Fatma Elzahraa Eid,Albert Chen,Ken Chan,Qin Huang,Qingxia Zheng,Isabelle Tobey,Simon Pacouret,Pamela Brauer,Casey Keyes,Megan Powell,Jencilin Johnston,Binhui Zhao,Alice Tarantal,Yujia A. Chan,Benjamin Deverman

MOLECULAR THERAPY（2023）

引用0浏览0引用

Targeting AAV Vectors to the CNS Via De Novo Engineered Capsid-Receptor Interactions

Qin Huang,Albert Chen,Ken Y. Chan,Hikari Sorensen,Andrew J. Barry,Bahar Azari,Thomas Beddow,Qingxia Zheng,Binhui Zhao,Isabelle G. Tobey,Fatma Elzahraa Eid,Alina Chan,Benjamin E. Deverman

MOLECULAR THERAPYno. 4 (2023): 228-229

引用6浏览0引用

A High-Efficiency AAV for Endothelial Cell Transduction Throughout the Central Nervous System

Trevor Krolak,Ken Y. Chan,Luke Kaplan,Qin Huang,Jason Wu,Qingxia Zheng,Velina Kozareva,Thomas Beddow,Isabelle G. Tobey,Simon Pacouret,Albert T. Chen,Yujia A. Chan, Daniel Ryvkin,Chenghua Gu,Benjamin E. Deverman

Nature cardiovascular research（2022）

引用41浏览0WOSNATURE引用

Fit4Function: A Machine Learning-Guided Approach for Systematic Multi-Trait AAV Capsid Engineering

Fatma-Elzahraa Eid,Ken Y. Chan,Albert T. Chen,Qin Huang,Isabelle G. Tobey,Qingxia Zheng,Simon Pacouret,Kasper Lage,Yujia Alina Chan,Benjamin E. Deverman

MOLECULAR THERAPY（2022）

引用0浏览0引用

A Promising New Family of Peptide-Modified AAV Capsids for Gene Delivery to the Central Nervous System in Non-Human Primates

Ken Y. Chan,Simon Pacouret,Qin Huang,Qingxia Zheng, Charles Vandenburg,Jason Wu,Pamela Brauer,Qiangge Zhang,Isabelle Tobey, Carolyn Wu,Albert T. Chen,Velina Kozareva,Guoping Feng,Benjamin E. Deverman

MOLECULAR THERAPY（2022）

引用0浏览0引用

Machine Learning-Accelerated Aav Engineering Through The Generation Of Production-Fit Capsid Libraries

Fatma-Elzahraa Eid,Ken Chan,Albert T. Chen,Isabelle G. Tobey,Qin Huang,Qingxia Zheng,Yujia Alina Chan,Ben Deverman

MOLECULAR THERAPY（2021）

引用0浏览0引用

Elucidating the Mechanism of Blood-Brain Barrier Transcytosis by the Engineered AAV-PHP.B Capsids: A Critical Step Towards Developing AAV Capsids for Human Gene Therapy

Qin Huang,Ken Chan,Isabelle Tobey,Tim Poterba,Christine Boutros,Alejandro B. Balazs, Jon Bloom,Cotton Seed,Benjamin E. Deverman

MOLECULAR THERAPY（2019）

引用0浏览0引用

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