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Dr. Ghobrial's research and clinical efforts focus on early detection and interception to prevent progression in Multiple Myeloma. She has a broad background in the biology of multiple myeloma and the bone marrow niche, specifically focusing on MGUS and Smoldering myeloma (SMM) and defining both cell-autonomous and bone marrow niche-dependent mechanisms of disease progression. Her group examines genetic and epigenetic alterations that regulate clonal progression and the role of the bone marrow niche in disease progression from early precursor stages (MGUS and SMM) to active Multiple Myeloma. She is the PI of PROMISE and PCROWD, observational cohort studies that are screening 30,000 individuals and following over 3,000 patients with MGUS and SMM. She has led several clinical trials in high-risk smoldering myeloma including immunotherapeutic precision interventions. All of these pursuits are focused on understanding and preventing the development of myeloma and other hematological malignancies.
Dr. Ghobrial's laboratory research is focused on understanding how early precursor conditions like MGUS and SMM progress to overt MM. We examine the genetic, epigenetic, and immune alterations that clonal progression and the role of the bone marrow niche in disease progression to active Multiple Myeloma. We work to understand the biological changes that occur during progression and develop therapeutic strategies to stop progression in its tracks. In addition, her research has been translated to innovative investigator-initiated clinical trials. She has led over 15 phase I and II clinical trials, and studies on the bone marrow and immune microenvironments are currently being translated into immunotherapy trials in high-risk precursor patients.
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论文共 773 篇作者统计合作学者相似作者
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Cancer Researchno. 6_Supplement (2024): 3447-3447
JMIR research protocols (2024): e51368-e51368
Clinical cancer research : an official journal of the American Association for Cancer Researchno. 4 (2024): 922-922
Clinical cancer research : an official journal of the American Association for Cancer Researchno. 4 (2024): 920-920
Yoshinobu Konishi, Giuseppe Tarantino, Yiwen He,Romanos Sklavenitis-Pistofidis, Sujal I. Shah, Katherine Towle,Christian J. Cea-Curry,Oksana Zavidij,Ruben D. Carrasco, Scott J. Rodig, Jon C. Aster, David Liu,
Cancer Researchno. 6_Supplement (2024): 5186-5186
Aldo M Roccaro, Antonio Sacco, Xiaojing Jia,Ranjit Banwait,Patricia Maiso,Feda Azab,Ludmila Flores,Salomon Manier,Abdel Kareem Azab,Irene M Ghobrial
Clinical cancer research : an official journal of the American Association for Cancer Researchno. 4 (2024): 919-919
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