Dr. Borecki has over 35 years of experience in statistical and genetic analysis of complex human traits, integrating epidemiologic, biometrical, genomic, and bioinformatic approaches. She has contributed to the development and evaluation of novel statistical methods and to the construction of analysis pipelines for genomic analysis. Her main research interests have been in cardiovascular disease and its risk factors, with an emphasis on obesity, fat patterning, fatty liver disease, and metabolic disorders of lipid and glucose metabolism. In addition to genomic approaches, she has investigated the role of the gut microbiome in metabolic and inflammatory disorders, specifically, pediatric NAFLD. She has also worked in the areas of breast, prostate and cervical cancer risk and progression, considering interactions between host and pathogen. She has played a leadership role in many collaborative projects, including the CHARGE and GIANT consortia, and for the TOPMed Program. Her lab has contributed to the management and analysis of genomic data, meta-analysis, and gene set (pathway) analysis, pleiotropy, and bioinformatic analysis. She has built and managed a team of analysts and informaticians to build a high-throughput analytical pipeline in a cloud environment to facilitate genomic discovery of therapeutic targets. She has also taught graduate and post-graduate trainees, and mentored interns, students, and junior faculty. She is now Chair of the Steering Committee for the NHLBI BioData Catalyst program (https://biodatacatalyst.nhlbi.nih.gov/), in which we develop cloud-based research platforms for the storage of large high-value epidemiological and genomic datasets, provide tools for searching and indexing and deep learning, analytics, and visualizations for the scientific community to push insights to new biology and therapeutic approaches for heart, lung and blood diseases.