He is a renowned physician-scientist whose work focuses on the characterization of signaling pathways altered in primary brain tumors and on early phase clinical trials with novel drugs targeting these pathways. He has made significant contributions to our understanding of the epidermal growth factor receptor in glioblastoma, the isocitrate dehydrogenase mutation in low‐grade gliomas, and the B cell receptor signaling axis in central nervous system lymphoma. More recently, Dr. Mellinghoff expanded his work to the development of biomarkers, such as cell‐free DNA in cerebrospinal fluid and various imaging approaches.