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A major interest of mine has been in the design and synthesis of Mn porphyrin(MnP)-based powerful catalytic antioxidants which helped establish structure-activity relationship (SAR). It relates the redox property of metalloporphyrins to their ability to remove superoxide. SAR has facilitated the design of redox-active therapeutics and served as a tool for mechanistic considerations. Importantly SAR parallels the magnitude of the therapeutic potential of SOD mimics and is valid for all classes of redox-active compounds. Two lead Mn porphyrins are already in five Phase II clinical trials (reviewed in Batinic-Haberle et al, Oxid Med Cell Longevity 2021). Recent research suggests immense potential of MnPs in cardiac diseases. MnTE-2-PyP (AEOL10113, BMX-010) prevents and treats cardiac arrhythmia, while MnTnBuOE-2-PyP (BMX-001) fully suppressed the development of aortic sclerosis in mice. The latter result is relevant to the cancer patients undergoing chemotherapy. In addition to breast cancer, in collaboration with Angeles Alvarez Secord, MD, MHSc, we have recently shown the anticancer effects of Mn porphyrin/ascorbate in cellular and mouse models of ovarian cancer.
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International Journal of Molecular Sciencesno. 6159 (2023): 6159-6159
Antioxidants (Basel, Switzerland)no. 10 (2023): 1861-1861
Ghadeer Abbas, Fatemah Alibrahim, Rawan Kankouni, Sara Al-Belushi,Dalal A. Al-Mutairi,Artak Tovmasyan,Ines Batinic-Haberle,Ludmil Benov
FREE RADICAL RESEARCHno. 6-12 (2023): 487-499
Sudha Sharma, Foram Patel,Hosne Ara,Ezra Bess,Alika Shum,Susmita Bhattarai,Utsab Subedi, Daquonte Sanard Bell,Md. Shenuarin Bhuiyan,Hong Sun,Ines Batinic-Haberle,Manikandan Panchatcharam,
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