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Characterisation of the novel mechanism of calicivirus protein synthesis
We have recently reported that caliciviruses use a novel protein-directed translation initiation mechanism that involves the binding of translation initiation factors to the VPg protein that is covalently linked to the 5’ end of the viral RNA (Goodfellow et al. EMBO Reports 2005, Chaudhry et al. JBC 2006). This mechanism has not seen in any other animal RNA virus, but shares some limited similarity with a mechanism proposed for members of the plant potyvirus family. We demonstrated that calicivirus translation initiation requires the interaction of host cell translation initiation factors with a virus encoded protein covalently linked to the viral RNA genome. Current work focuses on the proteomic analysis of the components of the calicivirus translation initiation complex, structural analysis of the roles of other translation initiation factors in calicivirus translation, as well as the identification of inhibitors of this novel translation mechanism as potential anti-viral therapeutics.
Characterisation of the novel mechanism of calicivirus protein synthesis
We have recently reported that caliciviruses use a novel protein-directed translation initiation mechanism that involves the binding of translation initiation factors to the VPg protein that is covalently linked to the 5’ end of the viral RNA (Goodfellow et al. EMBO Reports 2005, Chaudhry et al. JBC 2006). This mechanism has not seen in any other animal RNA virus, but shares some limited similarity with a mechanism proposed for members of the plant potyvirus family. We demonstrated that calicivirus translation initiation requires the interaction of host cell translation initiation factors with a virus encoded protein covalently linked to the viral RNA genome. Current work focuses on the proteomic analysis of the components of the calicivirus translation initiation complex, structural analysis of the roles of other translation initiation factors in calicivirus translation, as well as the identification of inhibitors of this novel translation mechanism as potential anti-viral therapeutics.
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STAR Protocolsno. 1 (2024): 102913-102913
Ashley Priddey,Michael Xin Hua Chen-Xu,Daniel James Cooper, Serena Macmillan,Georg Meisl,Catherine K. Xu,Myra Hosmillo,Ian G. Goodfellow, Rafael Kollyfas,Rainer Doffinger,John R. Bradley,Irina I. Mohorianu,
FRONTIERS IN IMMUNOLOGY (2024): 1296148-1296148
Ashley Priddey,Michael Xin Hua Chen-Xu,Daniel James Cooper, Serena Macmillan,Georg Meisl,Catherine K. Xu,Myra Hosmillo,Ian G. Goodfellow, Rafael Kollyfas,Rainer Doffinger,John R. Bradley,Irina I. Mohorianu,
Frontiers in Immunology (2024): 1296148-1296148
VIRUSES-BASELno. 2 (2024): 247
Communications biologyno. 1 (2023): 277
Ganna Kovalenko,Anna Yakovleva,Pavlo Smyrnov,Matthew Redlinger,Olga Tymets,Anna Korobchuk, Anna Kolodiazieva, Anna Podolina, Svitlana Cherniavska,Britt Skaathun,Laramie R Smith,Steffanie A Strathdee,
PNAS nexusno. 3 (2023)
Scientific reportsno. 1 (2023): 2555-1
SCIENTIFIC REPORTSno. 1 (2023)
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