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个人简介
Research Interests:
Research in my lab is related to immune recognition of microbial pathogens. We have structurally characterized many key antigen recognition receptors in innate and adaptive immunity, including T cell receptors, MHC class I and II, antibodies and antibody complexes, CD1, TLRs, VLRs, NODs, etc. We currently focus on viral glycoproteins from influenza, HIV-1, HCV, and SARS-CoV-2 and other enveloped viruses using x-ray crystallography and other biophysical approaches. We identify sites of vulnerability on HIV-1, influenza virus, HCV, SARS-CoV-2 and related CoVs, and P. falciparum malaria parasite, that are targeted by broadly neutralizing and protective antibodies, why these antibodies are so effective, and how we can use this information for structure-based design of vaccines and therapies, including antibody therapeutics.
研究兴趣
论文共 982 篇作者统计合作学者相似作者
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Andrew J. Thompson, Nicholas C. Wu,Angeles Canales,Chika Kikuchi,Xueyong Zhu,Beatriz Fernández de Toro, Francisco J. Cañada, Charli Worth,Shengyang Wang,Ryan McBride,Wenjie Peng,Corwin M. Nycholat,
Cell host & microbeno. 2 (2024): 261-275.e4
Meng Yuan,Linghang Peng,Deli Huang,Amanda Gavin, Fangkun Luan, Jenny Tran, Ziqi Feng,Xueyong Zhu, Jeanne Matteson,Ian A. Wilson,David Nemazee
Structure (2024)
Structure (London, England : 1993)no. 7 (2023): 755-757
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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bioRxiv : the preprint server for biology (2023)
Cherrelle Dacon,Linghang Peng,Ting-Hui Lin,Courtney Tucker,Chang-Chun D. Lee,Yu Cong,Lingshu Wang,Lauren Purser, Andrew J. R. Cooper, Jazmean K. Williams,Chul-Woo Pyo,Meng Yuan,
CELL HOST & MICROBEno. 6 (2023): 1071-1072
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