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Dr. Fantus’ early research focused on the cellular and molecular mechanism of insulin resistance and the regulation of insulin receptor tyrosine kinase signaling. More recently he has studied glucose toxicity as it relates to both insulin action and the complications of diabetes, in particular diabetic nephropathy. His research has contributed to the understanding of the role of tyrosine phosphatases, oxidative stress and serine/threonine kinases in regulating insulin signaling and the contribution of the hexosamine biosynthesis pathway to the complications of diabetes. Current work is centered on the functional role of the proteins, thioredoxin-interacting protein, and the cellular non-receptor tyrosine kinase, Src, in the pathogenesis of diabetic nephropathy.
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AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISMno. 3 (2018): E201-E205
Huogen Lu,Elena Bogdanovic,Zhiwen Yu,Charles Cho,Lijiang Liu,Karen Ho,June Guo, Lucy S N Yeung, Reiner Lehmann,Harinder S Hundal,Adria Giacca,I George Fantus
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGYno. 12 (2015): 2963-2977
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