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As the population of obesity is increasing in many countries, much interest have been attracted to understand the mechanism underlying obesity and its related metabolic diseases. The current understanding of these questions is mainly at the transcriptional regulation and protein signal pathway levels. However, we do not understand how posttranscriptional RNA metabolism contributes to the metabolic homeostasis at physiological conditions and how these regulations are dysregulated in pathological conditions. My research specifically focuses on the role of transcriptome stability in metabolic homeostasis. Using adipocytes as a model system, we have developed a comprehensive platform covering computational analysis, molecular biology, and animal physiology characterization. We have identified a few key regulators such as Ybx2 and HuR proteins in the RNA stability regulation in adipose tissue and have generated genetic mouse models to study their physiological function and molecular mechanism.
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